Control of cardiac homeostasis and cardiocrine signaling by protein arginine methyltransferases (B07)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 464424253

The two protein arginine methyltransferases PRMT5 and PRMT7 are strongly down-regulated in failing human hearts. Our preliminary work unmasked that PRMT5 and PRMT7 exert strong cardiomyocyteintrinsic effects on splicing and histone methylation along with essential functions for mitochondrial function, cardiac contractility and microenvironmental integrity. Excessive subendocardial fibrosis in cardiomyocyte-specific Prmt-deficiency suggests a strong effect on cardiocrine signals. Thus together with other CRC 1550 projects, B07 will undertake an integrative approach to decode cardiomyocyte-intrinsic mechanisms of secretion of factors that direct non myocytes to induce fibrosis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1550: Molecular Circuits of Heart Disease
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professor Dr. Johannes Backs; Professor Dr. Christoph Dieterich