Role of ETV transcription factors in atrial cardiomyopathy (B08)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 464424253

Atrial cardiomyopathy is a complex and heterogenous disease that occurs in context of various clinical backgrounds. The molecular circuits of atrial cardiomyopathy have not been well characterized, which also explains the lack of efficient therapies. ETV transcription factors driven gene regulation was shown for various genes as KCNK3 that are involved in atrial remodelling processes. We will dissect how ETV1-7 transcription factors are involved in the regulation of the atrial KCNK3 potassium ion channel as well as the development of atrial cardiomyopathy subtypes and how they control chamber-specific transcriptional responses. Understanding the underlying mechanisms will be important for identifying new therapeutic targets.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1550: Molecular Circuits of Heart Disease
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professorin Dr. Constanze Schmidt