Effects of peripheral and CNS trauma on the brains of healthy and Parkinson´s Disease mouse models (B08* (A08))

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Experimental Models for the Understanding of Nervous System Diseases ; Molecular and Cellular Neurology and Neuropathology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 251293561

We demonstrated that glial cells react after TBI in an orchestrated temporal and regional manner, with a long-lasting rapid reaction of microglia and a subsequent astrocyte reaction, while NG2-glia (also known as oligodendrocyte progenitor cells) respond in a rapid but transient manner. Notably, the blockage of NG2-glia after brain injury leads to delayed wound closure probably associated with changes in the reaction and infiltration of peripheral and resident immune cells. Because trauma has been implicated in the development of Parkinson’s disease, we aim here to unravel the underlying mechanisms of the association between trauma, both TBI and peripheral, glia cells, inflammation, adult neurogenesis and Parkinson’s disease as a comorbidity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1149: Danger Response, Disturbance Factors and Regenerative Potential after Acute Trauma
• Applicant Institution: Universität Ulm
• Project Heads: Professorin Dr. Karin Danzer; Professorin Dr. Leda Dimou