Rhabdovirus vectors: Replication and re-targeting (A03)

• Fachliche Zuordnung: Virologie
• Förderung: Förderung von 1999 bis 2010
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5483103

Recombinant Negative Strand RNA viruses (NSV) are emerging as promising candidates for oncolytic virotherapy and other live virus applications. A disadvantage potentially jeopardizing applications of NSV is the lack of control options for RNA replication in critical tissue. We have started to evaluate the suitability of IRES elements to control rabies virus RNA replication. Here we suggest experiments towards the development of conditional (on/off) systems for RNA virus vectors based on IRESs. In addition, re-targeting and live imaging is being improved to study virus transport and delivery.

• DFG-Verfahren: Sonderforschungsbereiche
• Teilprojekt zu: SFB 455: Virale Funktionen und Immunmodulation
• Antragstellende Institution: Ludwig-Maximilians-Universität München
• Teilprojektleiter: Professor Dr. Karl-Klaus Conzelmann