Mechanisms underlying unconventional T cell function as decision points to prevent microbial spread via the lymph (C01)

• Subject Area: Immunology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 492620490

C01 hypothesises that lymph nodes (LN) which drain distinct tissues have a different capacity to limit bacterial spreading of specific classes of pathogens and that this is based on the function and LN-characteristic composition of unconventional T cells (UTC). C01 will apply novel genetic approaches to target all UTC instead of single T-cell receptor-based UTC lineages to unravel their function as a population. We hope that C01 will provide novel angles for host directed therapies against microbial dissemination.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1583: Decisions in Infectious Diseases (DECIDE)
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Head: Professor Dr. Wolfgang Kastenmüller