Role of crosstalk between γδ T cells and Langerhans cells in driving their mutual differentiation in the postnatal niche (A04)

• Subject Area: Immunology ; Developmental Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693

This project will explore the hypothesis that postnatal development of γδ T cells and Langerhans cells (LC) in epidermis and oral mucosa is highly dependent on the dynamic interplay of these two resident immune cells within the perinatal time window. The project aims to define the differentiation dynamics and molecular crosstalk between γδ T cells and LC in two distinct tissue niches, and will explore the role of microbial colonization during γδ T cell/LC differentiation and adaptation. This joint project brings expertise on γδ T cell development, advanced single cell sequencing approaches, and myeloid cell development to PILOT.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 359: Perinatal Development of Immune Cell Topology
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professorin Dr. Katrin Kierdorf; Dr. Sagar Sagar