Project Details
Projekt
Effects of neonatal wildling microbiota on the immune response to vaccination (A07)
Subject Area
Immunology
Term
since 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693
A07 will study the impact of the microbiota on the neonatal vaccine-induced germinal center reaction. The proposal is based on the investigators’ fundamental discoveries that “wildling” mouse microbiota tunes systemic immunity in a way that better reflects human immune responses than microbiota found under specific-pathogen-free conditions. The project explores the impact of wild microbiota 1) on the capacity of dendritic cells from young mice to mediate T cell help in influenza infections and 2) on vaccination. The groups have unique knowhow in modulating and analyzing the host-microbe interface, in particular at the level of a highly complex microbiota, which will be extremely useful for many projects in PILOT.
DFG Programme
CRC/Transregios
Subproject of
TRR 359:
Perinatal Development of Immune Cell Topology
Applicant Institution
Albert-Ludwigs-Universität Freiburg
