Long-lasting consequences of early-life influenza A virus infection for the tissue-resident memory T cell niche and susceptibility to secondary infections (A05)

• Subject Area: Immunology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693

A05 will investigate the long-lasting consequences of early-life influenza A virus (IAV) infections in terms of adaptation of the lung microenvironment and susceptibility to secondary bacterial infections later in life. In particular, the project will examine how IAV infections alter lung-resident immune cell populations. These alterations may contribute to the formation of tissue-resident memory T cell niches and affect the response to secondary pneumococcal infections in adulthood. A05 offers sophisticated single-cell analytics as well as lung infection models to the consortium.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 359: Perinatal Development of Immune Cell Topology
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professorin Dr. Dunja Bruder; Professor Dr. Jochen Hühn