Effects of maternal hyperlipidemia on embryo-derived macrophages and perinatal immune development (B09)

• Subject Area: Immunology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693

B09 will analyze how maternal hyperlipidemia affects embryonic Mφ, which are at the core of the C. Schulz’s research interests. Tools include temporal control of metabolic disease activity during pregnancy with low density lipoprotein receptor anti-sense oligonucleotides, cross fostering experiments, and long-term phenotyping of prenatally exposed mice. Furthermore, human placental pathology will be studied with a focus on embryo-derived Hofbauer Mφ and maternal decidua Mφ. PILOT will benefit from C. Schulz’s widely-recognized proficiency in tracing Mφ development from the embryo to postnatal life.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 359: Perinatal Development of Immune Cell Topology
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Christian Schulz