Dissecting the interplay between vacuolar contact site plasticity and sphingolipid homeostasis (P07)

• Subject Area: Cell Biology ; Biochemistry
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 467522186

This project will focus on the connection between the plasticity of membrane contact sites at the vacuole and membrane lipid homeostasis. The vacuolar Cvm1 protein forms membrane contact sites between the yeast vacuole and the endoplasmic reticulum, the mitochondria, and the peroxisomes. The project will focus on the molecular architecture of Cvm1 contact sites, determine how these control sphingolipid levels, and uncover their regulation in response to sphingolipid levels.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1557: Functional Plasticity encoded by Cellular Membrane Networks
• Applicant Institution: Universität Osnabrück
• Project Head: Dr. Ayelen Gonzalez Montoro