Regulation of cytokine receptor signaling plasticity by the subcellular membrane context (P13)

• Subject Area: Cell Biology ; Biophysics
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 467522186

This project will focus on class I/II cytokine receptors with important functions in hematopoiesis and immunity. These receptors activate downstream signaling via associated Janus kinases (JAKs). Assembly of cytokine receptor signaling complexes and activation of downstream effectors appear highly regulated by subcellular localization pointing to a key role of the membrane environment. The project will unravel how receptor assembly and effector recruitment is regulated by membrane properties and subcellular localization.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1557: Functional Plasticity encoded by Cellular Membrane Networks
• Applicant Institution: Universität Osnabrück
• Project Head: Professor Dr. Jacob Piehler