The impact of ROS, ferroptosis, glucose transport and IL-1 receptor signaling on the progression of ADPKD (A02)

• Subject Area: Nephrology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993

In the previous funding period, we identified calcium-activated chloride secretion induced by HIF-1α and mediated by the chloride channel Anoctamin 1 as a significant contributor to cyst growth in polycystic kidney disease. In this funding period, we will address the impact of HIF-induced but secretion-independent signaling pathways on cyst progression in vitro and in vivo by inhibition of GLUT1-mediated glucose transport, use of approved HIF-PHD inhibitors, antagonism of IL-1 receptor signaling, application of the antioxidant coenzyme Q10, and inhibition of ferroptosis.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
• Applicant Institution: Universität Regensburg
• Project Head: Privatdozent Dr. Björn Buchholz