Project Details
Projekt
TMEM16J in chronic kidney disease (A03)
Subject Area
Anatomy and Physiology
Nephrology
Nephrology
Term
since 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993
During the present funding period, a genome wide association study (project C6) demonstrated association of the proteins TMEM16J and SIGIRR with chronic kidney disease (CKD). Earlier work from our team demonstrated TMEM16J as an intracellular protein that inhibits intracellular Ca2+ signaling, which affects numerous cellular functions such as volume regulation, cell death and proliferation. TMEM16J, with the help of SIGIRR and PKP3, also controls inflammation in various tissues. We found that TMEM16J is expressed in the kidney and will determine its renal function and role in CKD. To this end, we study expression, function and the role of TMEM16J in mouse models for CKD, using TMEM16J knockout and knockin mice, and kidneys obtained from CKD patients.
DFG Programme
CRC/Transregios
Subproject of
TRR 374:
Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
Applicant Institution
Universität Regensburg
Project Heads
Professor Dr. Karl Kunzelmann; Professor Dr. Rainer Schreiber
