Mechanisms of and interventional strategies against Autosomal Dominant Tubulointerstitial Kidney Diseases (ADTKD) (C04)

• Subject Area: Nephrology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993

The main objective of our project is to improve the molecular understanding of ADTKD, enabling us to design and validate interventional strategies in cellular and murine models. We aim to establish novel causative genes for ADTKD and thereby hope to gain more insights into disease mechanisms. Furthermore, we will generate and analyze patient-derived tubular cells by RNA-sequencing and metabolomics in order to identify novel pathway signatures. Finally, we will use patient-derived cells and murine models to validate interventional strategies (antisense oligonucleotides and BRD4780), principally suitable for clinical applications.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
• Applicant Institution: Universität Regensburg
• Project Head: Professor Dr. Michael Wiesener