Investigation of Sequence–Structure Relationships in Interphase Chromatin (R11)

• Subject Area: General Genetics and Functional Genome Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 464588647

Despite the importance of chromatin structure, our understanding of DNA packaging and the regulatory mechanisms that take effect over long distances is limited. To tackle this challenge, we will generate large amounts of sequencing data to produce chromatin-interaction matrices in various cell types during the developmental stage, as well as from patients with chromosomal aberrations. Subsequently, we will use these experimental data to construct chromatin models with predictive power based on concepts from molecular simulations of coarse-grained polymers. In parallel, we will use targeted simulations to identify additional parameters (e.g., epigenetic factors) that influence chromatin folding.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1551: Polymer Concepts in Cellular Function
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professorin Dr. Susanne Gerber, Ph.D.; Professorin Dr. Susann Schweiger; Dr. Peter Virnau