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Cell-fate decision upon RNA sensing by RIG-I like receptors and viral restriction factors (A28*)

Subject Area Cell Biology
Term since 2023
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 369799452
 
We have recently demonstrated that RIG-I and OAS1 share ligand requirements regarding short dsRNAs with a 5’-triphosphate moiety. Both receptor systems influence the cell fate with RIG-I activation leading to type I IFN secretion and induction of an antiviral cellular state and OAS1/RNase L inhibiting viral replication via translational inhibition and ultimately cellular demise. We will decipher the molecular activation requirements of OAS1 and analyse how the intricate interplay of downstream events upon RIG-I and OAS1 and other viral restriction factors shape the cell fate and immunogenicity of the RNA sensing event in order to induce an effective antiviral immune response.
DFG Programme CRC/Transregios
Project Head Dr. Lars König
 
 

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