Role of EGF-like growth factors in immune regulation and tissue homeostasis during GvHD (B14)

• Subject Area: Immunology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634

The two EGF-like growth factors, Amphiregulin and HB-EGF, are strongly upregulated in their expression during GvHD and substantially influence its development and progression. It is our aim to dissect the role these factors play during the different stages of GvHD and determine how we can tailor novel approaches for the prophylaxis and treatment of GvHD, by the selective blockade or application of recombinant Amphiregulin and / or HB-EGF.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 221: Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation
• Applicant Institution: Universität Regensburg
• Project Heads: Muhammad Haroon Shaikh, Ph.D., since 1/2026; Professor Dr. Dietmar M.W. Zaiß