Struktur und Funktion des sigma-B-abhängigen Streßregulons in Bacillus subtilis

• Antragsteller: Professor Dr. Michael Hecker
• Fachliche Zuordnung: Stoffwechselphysiologie, Biochemie und Genetik der Mikroorganismen
• Förderung: Förderung von 1999 bis 2009
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5206026

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• A tyrosine kinase and its activator control the activity of the CtsR heat shock repressor in B. subtilis. EMBO J. 24, 3435-3445 (2005)
  Kirstein, J.; Zühlke, D.; Gerth, U.; Turgay, K. and Hecker, M.
  
• Comprehensive characterization of the contribution of individual sigB-dependent general stress genes to stress resistance of Bacillus subtilis. J. Bacteriol. 187, 2810-2826 (2005)
  Höper, D.; Völker, U. and Hecker, M.
  
• Fluorescence thiol modification assay: Oxidatively modified proteins in Bacillus subtilis. Mol. Microbiol. 58, 409-425 (2005)
  Hochgräfe, F.; Mostertz, J.; Albrecht, D. and Hecker, M.
  
• From genomics via proteomics to cellular physiology of the grampositive model organism Bacillus subtilis. Cell. Microbiol. 7, 1077-1085 (2005)
  Völker, U. and Hecker, M.
  
• Genome-wide mRNA profiling in glucose starved Bacillus subtilis cells. Mol. Gen. Genomics 274, 1- 12 (2005)
  Koburger, T.; Weibezahn, J.; Bernhardt, J.; Homuth, G. and Hecker, M.
  
• Salt stress adaptation of Bacillus subtilis: A physiological proteomics approach. Proteomics 6, 1550-1562 (2006)
  Höper, D.; Bernhardt, J. and Hecker, M.
  
• Spx is a global effector impacting on stress tolerance and biofilm formation in Staphylococcus aureus. J. Bacteriol. 188, 4861-4870 (2006)
  Pamp, S. H.; Frees, D.; Engelmann, S.; Hecker, M. and Ingmer, H.
  
• A disulfide bond-containing alkaline phosphatase triggers a BdbC-dependent secretion stress response in Bacillus subtilis. Appl. Environ. Microbiol. 72, 6876-6885 (2007)
  Darmon, E.; Dorenbos, R.; Meens, J.; Freudl, R.; Antelmann, H.; Hecker, M.; Kuipers, O. P.; Bron, S.; Quax, W. J.; Dubois, J.-Y. and van Dijl, J. M.
  
• Global regulatory systems mediating general starvation responses in Bacillus subtilis. In: Fujita, Y. (ed.): Global regulatory networks in Bacillus subtilis. pp. 205-228, Transworld Research Network, Kerala, India (2007)
  Mäder, U.; Homuth, G.; Völker, U. and Hecker, M.
  
• Scysteinylation is a general mechanism for thiol protection of Bacillus subtilis proteins after oxidative stress. J. Biol. Chem. 282, 25981-25985 (2007)
  Hochgräfe, F.; Mostertz, J.; Pöther, D.; Becher, D.; Helmann, J. and Hecker, M.
  
• SigB-dependent general stress response in Bacillus subtilis and related gram-positive bacteria. Annu. Rev. Microbiol. 61, 215-236 (2007)
  Hecker, M.; Pané-Farré, J. and Völker, U.
  
• Structural and functional chracterisation of partner-switching regulating the environmental stress response in B. subtilis. J. Biol. Chem. 282, 11562-11572 (2007)
  Hardwick, S. W.; Pané-Farré, J.; Delumeau, O.; Marles-Wright, J.; Murray, J. W.; Hecker, M. and Lewis, R. J.
  
• The tyrosine kinase McsB is a regulated adaptor protein for ClpCP. EMBO J. 26, 2061-2070 (2007)
  Kirstein, J.; Dougan, D. A.; Gerth, U.; Hecker, M. and Turgay, K.
  
• Nitric oxide stress induces different responses but mediates comparable protein thiol protection in Bacillus subtilis and Staphylococcus aureus. J. Bacteriol. 190, 4997-5008 (2008)
  Hochgräfe, F.; Wolf, C.; Fuchs, S.; Liebeke, M.; Lalk, M.; Engelmann, S. and Hecker, M.
  
• The role of the thioredoxin TrxA in Bacillus subtilis: A proteomics and transcriptomics approach. Proteomics 8, 2676-2690 (2008)
  Mostertz, J.; Hochgräfe, F.; Jürgen, B.; Schweder, T. and Hecker, M.
  
• The Spx paralogue MgsR (YqgZ) controls a subregulon within the general stress response of Bacillus subtilis. Mol. Microbiol. 69, 1104-1120 (2008)
  Reder, A.; Höper, D.; Weinberg, C.; Gerth, U.; Fraunholz, M. and Hecker, M.
  
• Physiological proteomics and stress/starvation responses in Bacillus subtilis and Staphylococcus aureus. Res. Microbiol. 160, 245-258 (2009)
  Hecker, M.: Reder, A.; Fuchs, S.; Pagels, M.; and Engelmann, S.