Stromal regulation of inflammation in pemphigoid diseases (B10*)

• Subject Area: Dermatology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 454193335

Pemphigoid diseases (PD) exhibit a relapsing-remitting disease pattern and a preferential affection of certain skin parts, suggesting that local cell populations facilitate regional inflammation. Our preliminary data suggest that dermal fibroblasts (DFs) get metabolically and functionally "primed" by repeated inflammation in the passive transfer model of epidermolysis bullosa acquisita and mediate progressive worsening. In the project, we will delineate the priming response of the skin and focus on mouse and human DFs and their interaction with PD-relevant inflammatory cells. We will also try to "un-prime" DFs by interfering with candidate pathways differentially regulated in primed DFs.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1526: Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU): Insights from Pemphigoid Diseases
• Applicant Institution: Universität zu Lübeck
• Project Head: Professor Dr. Markus Hoffmann