Targeted exploitation of inflammatory programs in SCLC (A08*)

• Subject Area: Cell Biology ; Hematology, Oncology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 413326622

M. Sos and his colleagues will investigate the impact of caspase-independent cell death elicited by chemotherapy or targeted therapy on the inflammatory response. The project is based on the observation that elevated sub-lethal levels of caspase activity contribute to the oncogenic state in SCLC and may suppress inflammatory response genes. The team will seek to analyze the mechanistic principles of caspase-dependent inflammatory signaling during therapeutic stress and activation status of the immune cell infiltrate on the single cell level in vivo. Furthermore, they will explore, to which extent combination therapies can be used to elicit synergistic effects by enhancing immunogenicity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1399: Mechanisms of drug sensitivity and resistance in small cell lung cancer
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Martin Sos, since 7/2023