Neural mechanisms underlying action-based predictions and their effects on perception (A10#)

• Subject Area: Human Cognitive and Systems Neuroscience
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 222641018

Virtually all movements that we make produce sensory input, thereby shaping a large part of our sensory world. Although research has shown that action affects perception and neural processing of such self-generated stimuli, the underlying mechanisms of these modulations are not wellunderstood. Furthermore, impaired action-based mechanisms have been linked to psychosis; however, it is not yet clear how they may lead to the false percepts involved in psychotic symptoms. Through the combination of univariate and multivariate analysis of functional MRI data, MR-spectroscopy, and behavioural methods, this project will shed light on the neural and neurochemical mechanisms underlying action-based modulations. Furthermore, we will test how action-based predictions may relate to altered perception in hallucination-prone healthy individuals.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 135: Cardinal mechanisms of perception: Prediction, Valuation, Categorization
• Applicant Institution: Justus-Liebig-Universität Gießen
• Project Head: Professorin Dr. Bianca van Kemenade, since 7/2023