Reciprocal transfer of knowledge from population-based genetic screens to whole-body, organ-resolved models of human metabolism (B06)

• Subject Area: Bioinformatics and Theoretical Biology ; Epidemiology and Medical Biometry/Statistics ; Nephrology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 499552394

We will transfer information from genetic association analyses into in silico models of human metabolism, and vice versa. Specifically, we will utilize whole-body models as an independent validation resource for metabolite-gene associations. The associations will be obtained from gene-based tests of rare, deleterious variants and their effect on metabolite levels in plasma and urine. Novel knowledge about human physiology and metabolism originating from these association studies will be fed back and continuously improve the whole-body models.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1597: Small Data
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professor Dr. Johannes Hertel; Professorin Dr. Anna Köttgen