Regulation of gene expression and activity of the alpha-secretase ADAM 10

Applicant Professor Dr. Falk Fahrenholz

Subject Area Molecular Biology and Physiology of Neurons and Glial Cells

Term from 2000 to 2008

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 5248896

Final Report Year 2008

Final Report Abstract

No abstract available

(2005) Genomic structure and functional characterization of the human ADAM10 promoter. FASEB J. 19, 1522-1524
Prinzen, C., Müller, U., Endres, K., Fahrenholz, F. and Postina, R.
(See online at https://doi.org/10.1096/fj.04-3619fje)
(2005). Shedding of the amyloid precursor protein-like protein APLP2 by disintegrinmetalloproteinases. FEBS J. 272, 5808-5820
Endres, K., Postina, R., Schroeder, A., Mueller, U., and Fahrenholz, F.
(2006). Alpha-secretase activation - an approach to Alzheimer's disease therapy. Neurodegener. Dis. 3, 255-261
Fahrenholz, F., and Postina, R.
(2008). Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases. J. Biol. Chem., Oct. 24 (epub ahead of print)
Zhang, L., Bukulin, M., Kojro, E., Roth, A., Metz, V.V., Fahrenholz, F., Nawroth, P.P., Bierhaus, A., and Postina, R.