Project Details
Projekt Print View

The role of epigenetic modifications in neuroblastoma evolution and plasticity (A05)

Subject Area General Genetics and Functional Genome Biology
Bioinformatics and Theoretical Biology
Developmental Biology
Pediatric and Adolescent Medicine
Term since 2023
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 493872418
 
The project aims to investigate the relationships between genetic and epigenetic influences in tumor evolution through bulk and single-cell sequencing studies of genomic and epigenomic profiles in spatially separated tumor tissue samples. Computational tools will be developed to analyze epigenetic trait responses to chemotherapeutic pressure and elucidate resistance mechanisms to epigenetically targeted drugs. The goal is to identify and validate biomarkers for clinical disease progression.
DFG Programme Collaborative Research Centres
Applicant Institution shared FU Berlin and HU Berlin through:
Charité - Universitätsmedizin Berlin
 
 

Additional Information

Textvergrößerung und Kontrastanpassung