Biomarkers and mechanisms of disease progression and outcome in aortic stenosis in humans (C06*)

• Subject Area: Cardiology, Angiology ; Immunology ; Nuclear Medicine, Radiotherapy, Radiobiology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 397484323

Early recognition and management of aortic stenosis (AS) are substantial to avoid life-threatening events during the clinical course. Complex mechanisms including fibrosis, oxidative stress, inflammation, angiogenesis, osteogenic differentiation and the effect of genetic risk variants have been proposed to be involved mechanistically in the pathogenesis of degenerative AS. In our project, we plan to assess multiple morphological, functional, genetic and immunological parameters and combine these parameters for model development, applying deep learning algorithms, to investigate their capacity to predict disease progression in patients with moderate AS in a longitudinal long-term clinical study.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 259: Aortic Disease
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Bernardo Franklin, since 7/2023; Privatdozent Dr. Julian Alexander Luetkens, since 7/2023; Dr. Victor Mauri, since 7/2023; Dr. Jasmin Shamekhi, since 7/2023; Verena Veulemans, Ph.D., from 7/2023 until 5/2024; Professor Dr. Tobias Zeus, since 6/2024