Spontaneous and treatment-induced T cell responses against neuroblastoma (C05)

• Subject Area: Hematology, Oncology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 493872418

Project C05 aims to compensate for impaired antigen recognition in MYCN-amplified neuroblastoma. First, antigen processing in mouse models and human tumors will be analyzed to determine differences in antigen recognition due to MYCN. In addition, the relationship between tumor-specific CD8+ and CD4+ T cells in the tumor microenvironment will be investigated and the efficacy of a combination of oncogene-specific CD8+ and CD4+ T cells will be tested. Furthermore, how TCR-engineered T cells can target immunogenic neuroblastoma-specific antigens to avoid off-target effects will be investigated.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1588: Decoding and Targeting Mechanisms of Neuroblastoma Evolution
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Head: Professor Dr. Gerald Willimsky