The role of neuroblastoma-secreted exosomes in pre-metastatic niche formation (C06)

• Subject Area: Hematology, Oncology ; Pediatric and Adolescent Medicine
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 493872418

In this project, the interactions between exosomes of neuroblastoma cells and endothelial layers in zebrafish will be investigated. For this, fluorescence imaging, bulk RNA-Seq and proteomics will be used to characterize proangiogenic or invasion-associated signatures and identify potential endothelial signatures as biomarkers. The results will be used to interrupt the invasion/metastasis cascade and progression of highly malignant neuroblastoma.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1588: Decoding and Targeting Mechanisms of Neuroblastoma Evolution
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Dr. Hedwig E. Deubzer, Ph.D.; Professor Dr. Holger Gerhardt