Self-regulating enhanced surfaces for autonomously operated bioprocesses (A04)

• Subject Area: Technical Chemistry ; Automation, Mechatronics, Control Systems, Intelligent Technical Systems, Robotics
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 503850735

This project focuses on the development of microsystem substrates and the integration of smart materials enabling enhanced surfaces for bioprocesses. The enzymatic cofactor regeneration of NAD to NADH by hydrogenase using in situ generated H2 will be taken as a model reaction. This model reaction will be realised in a microsystem carrier with integrated electrodes and optical waveguides enabling space-resolved biocatalytic reaction sequences with controllable individual steps. Our novel approach of combining 3D manufacturing with microsystems technology will pave the ground for a new generation of adaptive components for future SMART bioreactors.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1615: SMART Reactors for Future Process Engineering
• Major Instrumentation: Printer for 3D metal interconnection
• Instrumentation Group: 2110 Formen-, Modellherstellung und gießereitechnische Maschinen
• Applicant Institution: Technische Universität Hamburg
• Project Heads: Professor Dr. Andreas Liese; Professor Dr.-Ing. Hoc Khiem Trieu