Magnetic resonance imaging with photo-CIDNP signal enhancement ((1) A01)

• Subject Area: Biochemistry
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514664767

In magnetic resonance imaging (MRI) and micro-MRI (MRI), the lack of signal and of contrast often are the limiting factors in medical diagnosis. Production of nuclear hyperpolarization can overcome this problem. To this end, we aim to introduce the solid-state photo-CIDNP effect into MRI. The solid-state photo-CIDNP (photochemically induced dynamic nuclear polarization) effect occurs in light-induced transient spin correlated radical pairs in, e.g., photosynthetic reaction centers and in flavoproteins. These molecular agents, converting light into nuclear hyperpolarization, will be applied as contrast agent in MRI studies.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 386: HYP*MOL – Hyperpolarization in molecular systems
• Applicant Institution: Universität Leipzig
• Project Heads: Professorin Dr. Alia Alia Matysik; Professor Dr. Jörg Matysik