Apoptosis and survival in response to TRAIL signaling in human B cell homeostasis (A01)

• Subject Area: Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 471011418

Although TRAIL-induced apoptosis has been reported to be selective for tumor cells, there is increasing evidence that TRAIL initiates downstream signals, including apoptosis, also in primary cells. This project will investigate the cell death-promoting activities of TRAIL in primary human B cells, and will define the subpopulations and developmental stages of B cells, which are resistant or sensitive to TRAIL receptor activation. It will further identify the decision-making processes, which result in differential sensitivity of human B cell populations.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 353: Regulation of cell death decisions
• Applicant Institution: Universität Konstanz
• Project Head: Professorin Dr. Marta Rizzi