Investigating cell type-specific death-survival decisions imposed by constitutively active RAS signaling (A06)

• Subject Area: Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 471011418

Apoptosis resistance has been considered as a hallmark of cancer, yet cancer cells are often highly sensitive to apoptosis triggers. In a model of oncogenic RAS-driven juvenile myelomonocytic leukemia (JMML) this project will investigate how mitochondrial priming and signal integration by the BCL-2 hub regulate cell death decisions. To address differences between primary cells versus tumor cells, it will study these processes in conditionally immortalized primary murine myeloid cells, murine leukemia cells and human JMML xenografts.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 353: Regulation of cell death decisions
• Applicant Institution: Universität Konstanz
• Project Head: Professorin Dr. Miriam Erlacher