Death pores: decision-making at the execution step of regulated necrosis (A10)

• Subject Area: Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 471011418

Terminal execution is a distal decision in regulated cell death. This project will investigate how terminal execution of pyroptosis and necroptosis are regulated by a balanced activation of pore-forming proteins and membrane repair. Using optogenetic approaches to activate pore-forming proteins, the project will study the extent of plasma membrane permeabilization that a cell can tolerate during pyroptosis and necroptosis induction before the decision to die is made.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 353: Regulation of cell death decisions
• Applicant Institution: Universität Konstanz
• Project Head: Professorin Dr. Ana Jesús Garcia Sáez