Oxidative cell death decisions in response to localized peroxide challenges (B05)

• Subject Area: Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 471011418

Ferroptosis is a specific form of oxidative cell death involving excessive lipid peroxidation. It is currently, however, unclear which subcellular compartments are targeted by lipid peroxidation during ferroptosis, and how these processes differ from other ROS-dependent forms of cell death. Employing an organelle-specific model of ROS generation this project will investigate which organelles are targeted by ferroptosis, and how these processes are counteracted by glutathione peroxidase 4 and thioredoxin reductase.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 353: Regulation of cell death decisions
• Applicant Institution: Universität Konstanz
• Project Head: Dr. Marcus Conrad