TNF receptor family signaling in modulating decision processes in apoptotic and necrotic liver cell death (B08)

• Subject Area: Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 471011418

The liver is exposed to a large variety of stimuli and drugs, which can promote hepatocyte death through different cell death modalities, i.e. apoptosis versus necrotic types of cell death. Of interest, members of the TNF superfamily, especially TRAIL, fail to promote hepatocyte death directly, yet enhance cell death induction by other triggers, including necrosis-promoting drugs, such as paracetamol. This project will investigate the role of BCL-2 family members and energy metabolism in the execution of hepatocyte cell death by different cell death modalities, and how TNF family members regulate these processes.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 353: Regulation of cell death decisions
• Major Instrumentation: live cell imaging system
• Instrumentation Group: 5000 Labormikroskope
• Applicant Institution: Universität Konstanz
• Project Head: Professor Dr. Thomas Brunner