Project Details
Projekt
Modulation of cortical inhibition by transcranial magnetic stimulation in rodents and humans – network effects and molecular mechanisms (B03)
Subject Area
Cognitive, Systems and Behavioural Neurobiology
Term
since 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 514483642
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique, which modulates cortical excitability beyond the stimulation period. Despite its clinical use it remains unclear if and how TMS mediates changes in synaptic transmission, neuronal excitability, and network activity. We investigate network effects and the underlying molecular mechanisms of TMS protocols in cortical circuits of mice and humans, focusing on parvalbumin-expressing basket cells and somatostatin-expressing dendritic inhibitory interneurons. Our major goal is to identify the cellular and molecular mechanisms of clinically approved TMS on interneuron function and plasticity.
DFG Programme
CRC/Transregios
Applicant Institution
Albert-Ludwigs-Universität Freiburg
Project Heads
Professor Dr. Jörg Geiger; Professor Dr. Andreas Vlachos
