Anatomical organization of inhibitory microcircuits in the human temporal cortex (B07)

• Subject Area: Cognitive, Systems and Behavioural Neurobiology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514483642

In this project, we will obtain high-resolution neuroanatomical data, complementary to physiological and molecular information, on the diversity of interneurons (INs) in upper layers of human and mouse temporal cortex. By combining whole-cell multi-patch recordings with light and electron microscopic analysis, we will investigate the structural basis and functional impact of mutual inhibitory interactions mediated by ionotropic GABAA and metabotropic GABAB receptors among IN types. Our research will, thus, provide essential data on microcircuit embedding of cortical INs, with species-specific aspects, for a better understanding of how these neurons contribute to encoding of information.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 384: Inhibitory neurons: shaping the cortical code (IN-CODE)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Dr. Sabine Grosser; Professor Dr. Imre Vida