Arginine supplementation as new therapeutic option against inflammatory bone loss (B05)

• Subject Area: Immunology ; Rheumatology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 501752319

Project B05 wants to test the ability of arginine and its metabolites to inhibit osteoclastogenesis and block inflammatory bone loss. Our goal is to elucidate the outcome of L-arginine supplementation in protective and therapeutic application during arthritis development as well as to define the importance of L-arginine catabolic enzymes such as arginase-1 and/or -2 expression in myeloid cells. Such approach would allow protection against bone loss by inhibition of inflammation and a metabolic reprogramming of the macrophages and osteoclasts.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 369: DIONE Degeneration of bone induced by inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Professorin Dr. Aline Bozec, Ph.D.; Privatdozentin Dr. Ulrike Schleicher