Regulation of autoantibody in-duced bone inflammation and osteoclastogenesis via the C-type lectin receptor Mincle (C01)

• Subject Area: Immunology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 501752319

Project C01 will investigate the crosstalk between canonical FcgRs and the C-type lectin receptor Mincle in the context of inflammatory bone loss. Depending on ligand availability, independent sets of receptors may compete for the common FcRg-chain to trigger downstream activation of tyrosine-protein kinase SYK and phosphoinositide (PI)3 kinase to generate osteoclasts. The long-term goal of the project is to create an interaction map of FcRg-chain dependent cell surface receptors expressed during inflammatory osteoclastogenesis allowing identifying positive and negative checkpoints involved in inflammatory bone remodelling.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 369: DIONE Degeneration of bone induced by inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Head: Professor Dr. Falk Nimmerjahn