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Molekulare und zelluläre Mechanismen der Angiogenese im Rahmen entzündlicher Prozesse: Die Rolle neutrophiler Granulozyten
Antragstellerin
Professorin Dr. Barbara Walzog
Fachliche Zuordnung
Anatomie und Physiologie
Förderung
Förderung von 2001 bis 2006
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5303986
Erstellungsjahr
2007
Zusammenfassung der Projektergebnisse
Keine Zusammenfassung vorhanden
Projektbezogene Publikationen (Auswahl)
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(2003) A role for apoptosis in the control of neutrophil homoeostasis in the circulation: Insights from CD18-deficient mice. Blood 101, 739-746
Weinmann, P., Scharffetter-Kochanek, K., Peters, T., Walzog, B.
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(2003) A role for syk-kinase in the control of the binding cycle of the β2 integrins (CD11/CD18) in human polymorphonuclear neutrophils. J. Leukoc. Biol. 74: 260-269
Willeke, T., Schymeinsky, J., Prange, P., Zahler, S., Walzog, B.
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(2004) Delay of neutrophil apoptosis in acute coronary syndromes is mediated by cytokines and platelets. J. Leukoc. Biol. 75: 828-835
Garlichs, C., Eskafi, S., Schmeisser, A., Walzog, B., Raaz, D., Bremer, J.R., Daniel, W.G.
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(2004) Identification of caspase-10 in human neutrophils: A role in spontaneous but not in inflammation-mediated apoptosis. J. Leukoc. Biol. 75: 836-843
Goepel, F., Weinmann, P., Walzog, B.
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(2005) Blut. In: Klinke, R., Pape, H.-C., Sibernagl, S. (Hrsg.) Lehrbuch der Physiologie, 5. Aufl., pp. 223-254, Thieme, Stuttgart
Bauer, C., Walzog, B.
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(2005) Human neutrophils promote angiogenesis by a paracrine feedforward mechanism involving endothelial interleukin-8. Am. J. Physiol. Heart Circ. Physiol. 288: H1186-1192
Schruefer, R., Lutze, N., Schymeinsky, J., Walzog, B.
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(2005) Mechanisms of inflammation: neutrophils. In: Hamann, A., Endelhardt, B. (Hrsg.) Leukocyte Trafficking, pp. 248-268, Wiley-VCH, Weinheim
Sperandio, M., Walzog, B.
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(2005) The non-receptor tyrosine kinase Syk regulates lamellipodium formation and site-directed migration of human leukocytes. J. Cell Physiol. 204: 614-622
Schymeinsky, J., Then, C., Walzog, B.
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(2005) Wound-healing defect of CD18-/- mice due to a decrease in TGB-β1 and myofibroblast differentiation. EMBO J. 24:3400-3410
Peters, T., Hinrichs, R., Hinz, B., Holzwarth, K., Menke, A., Al-Azzeh, E., Sulyok, S., Walzog, B., Oreshkova, T., Sindrilaru, A., Sunderkötter, C., Wlaschek, M., Krieg, T., Scharffetter- Kochanek, K.
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(2006) Midkine - A novel proangiogenic cytokine in human polymorphonuclear neutrophils. 24th European Conference on Microcirculation, 30.8.- 2.9.2006, Amsterdam, Netherlands. J. Vasc. Res. 43: 76
Groesser L., Schruefer, R., Walzog, B.
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(2006) The proangiogenic capacity of polymorphonuclear neutrophils delineated by microarray technique and by measurement of neovascularization in wounded skin of CD18-deficient mice. J. Vasc. Res. 43:1-11
Schruefer, R., Sulyok, S., Schymeinsky, J., Peters, T., Scharffetter-Kochanek K., Walzog, B.
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(2006) The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for β2 integrin (CD11/CD18)-mediated leukocyte polarization and migration. Blood 108: 3919-3927
Schymeinsky, J., Sindrilaru, A., Formmhold, D., Sperandio, M., Gerstl, R., Then, C., Mócsai, A., Scharffetter-Kochanek, K., Walzog, B.