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GSC 270:  International Graduate School in Molecular Medicine Ulm

Subject Area Medicine
Term from 2007 to 2019
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 53244728
 
Final Report Year 2019

Final Report Abstract

Ulm University founded the International Graduate School in Molecular Medicine Ulm (IGradU) in 2006 to provide high-quality postgraduate training. IGradU has been supported by the Excellence Initiative since 2007. The goal of IGradU was, and still is, to introduce doctoral candidates at Ulm University conducting research in the field of biomedicine to a structured postgraduate programme. Key research areas cover neurobiology, ageing & degeneration, oncology & endocrinology, virology, microbiology & biotechnology, systems biology, development & regeneration as well as trauma research and immune modulation. There are two structured training programmes on offer: the International PhD Programme in Molecular Medicine for doctoral candidates in natural sciences and the Experimental Medicine programme for doctoral candidates in medicine. As of 31 July 2019, 272 candidates have completed the PhD programme and 156 are enrolled. IGradU is run by a board, which in turn is advised by an international advisory committee. The International PhD Programme in Molecular Medicine offers a three-year structured doctorate including two intermediate evaluations. Admission regulations stipulate clear criteria for selection. During their postgraduate course, doctoral candidates are monitored by a Thesis Advisory Committee (TAC) made up of three supervisors. Graduates opt to receive either the international academic title of PhD or the German academic title Dr. rer. nat. In order to combat deficiencies in the supervision and quality of medical theses, the Medical Faculty implemented the structured training programme Experimental Medicine in 2005, which was subsequently adopted by IGradU in 2010. The Experimental Medicine programme is defined as a first step in the training of clinician scientists. The entry requirement for the programme is an above-average intermediate examination (part one of the national medical licensing exam). Doctoral candidates must interrupt their studies in medicine for nine months to concentrate fully on their experimental work. Doctoral candidates present their research in the programme's seminars and present up-to-date scientific literature in a Journal Club. A Junior Faculty was established during the second funding period. Young researchers who receive third-party funding for PhD students but are not yet allowed to be first supervisor due to the lack of a higher qualification (Habilitation) are organized within this group of scientists. Within IGradU, members of the Junior Faculty will be allowed to participate in TACs. Members of the Junior Faculty will be trained for their future career by providing additional training opportunities that concentrate on (i) academia; (ii) industry; or (iii) strengthening the training of clinician scientists. 2 Finally, IGradU served as a role model for the implementation of the Graduate & Professional Training Center Ulm (ProTrainU) that provides support for young scientist at the level of Ulm University.

Link to the final report

https://dx.doi.org/10.2314/KXP:1698163444

Publications

  • Increased copper toxicity in Saccharomyces cerevisiae lacking VPS35, a component of the retromer and monogenic Parkinson disease gene in humans. Biochem Biophys Res Commun. 2016 Aug 5;476(4):528-533
    Sowada N, Stiller B, Kubisch C
    (See online at https://doi.org/10.1016/j.bbrc.2016.05.157)
  • Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation. EMBO J. 2011 Feb 2;30(3):569-81
    Grabrucker AM, Knight MJ, Proepper C, Bockmann J, Joubert M, Rowan M, Nienhaus GU, Garner CC, Bowie JU, Kreutz MR, Gundelfinger ED, Boeckers TM
    (See online at https://doi.org/10.1038/emboj.2010.336)
  • Inferring Boolean network structure via correlation. Bioinformatics. 2011 Jun 1;27(11):1529-36
    Maucher M, Kracher B, Kühl M, Kestler HA
    (See online at https://doi.org/10.1093/bioinformatics/btr166)
  • A boolean model of the cardiac gene regulatory network determining first and second heart field identity. PLoS One. 2012;7(10):e46798
    Herrmann F, Groß A, Zhou D, Kestler HA, Kühl M
    (See online at https://doi.org/10.1371/journal.pone.0046798)
  • Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature. 2012 Apr 29;486(7402):256-60
    Schmeisser MJ, Ey E, Wegener S, Bockmann J, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, Dieck St, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED, Boeckers TM
    (See online at https://doi.org/10.1038/nature11015)
  • Multiscale binarization of gene expression data for reconstructing Boolean networks. IEEE/ACM Trans Comput Biol Bioinform. 2012;9(2):487-98
    Hopfensitz M, Mussel C, Wawra C, Maucher M, Kühl M, Neumann H, Kestler HA
    (See online at https://doi.org/10.1109/TCBB.2011.62)
  • Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses. Nat Nanotechnol. 2013 Feb;8(2):130-6
    Yolamanova M, Meier C, Shaytan AK, Vas V, Bertoncini CW, Arnold F, Zirafi O, Usmani SM, Müller JA, Sauter D, Goffinet C, Palesch D, Walther P, Roan NR, Geiger H, Lunov O, Simmet T, Bohne J, Schrezenmeier H, Schwarz K, Ständker L, Forssmann WG, Salvatella X, Khalatur PG, Khokhlov AR, Knowles TP, Weil T, Kirchhoff F, Münch J
    (See online at https://doi.org/10.1038/NNANO.2012.248)
  • The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing. PLoS One. 2013 Dec 31;8(12):e84232
    Heilmann A, Schinke T, Bindl R, Wehner T, Rapp A, Haffner-Luntzer M, Nemitz C, Liedert A, Amling M, Ignatius A
    (See online at https://doi.org/10.1371/journal.pone.0084232)
  • Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nat Commun. 2014 Apr 1;5:3508
    Usmani SM, Zirafi O, Müller JA, Sandi-Monroy NL, Yadav JK, Meier C, Weil T, Roan NR, Greene WC, Walther P, Nilsson KP, Hammarström P, Wetzel R, Pilcher CD, Gagsteiger F, Fändrich M, Kirchhoff F, Münch J
    (See online at https://doi.org/10.1038/ncomms4508)
  • Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides. Sci Transl Med. 2014 Nov 12;6(262):262ra157
    Zirafi O, Kim KA, Roan NR, Kluge SF, Müller JA, Jiang S, Mayer B, Greene WC, Kirchhoff F, Münch J
    (See online at https://doi.org/10.1126/scitranslmed.3009634)
  • The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of Photorhabdus luminescens ADP-ribosyltransferases. Cell Microbiol. 2014 Apr;16(4):490-503
    Lang AE, Ernst K, Lee H, Papatheodorou P, Schwan C, Barth H, Aktories K
    (See online at https://doi.org/10.1111/cmi.12228)
  • Unlabeling data can improve classification. Pattern Recognition Letters, 37:15–23, 2014
    Lausser L, Schmid F, Schmid M, Kestler HA
    (See online at https://doi.org/10.1016/j.patrec.2013.03.027)
  • (2015): Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration. Journal of visualized experiments: JoVE, e52756
    Wehner D, Jahn C, and Weidinger G
    (See online at https://doi.org/10.3791/52756)
  • A molecular tweezer antagonizes seminal amyloids and HIV infection. elife. 2015 Aug 18;4
    Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klärner FG, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J, Münch J
    (See online at https://doi.org/10.7554/eLife.05397.001)
  • Haploinsufficiency of TBK1causes familial ALS and fronto-temporal dementia. Nat Neurosci. 2015 May;18(5):631-6
    Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Müller K, Marroquin N, Nordin F, Hübers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordström U, Feiler MS, Putz S, Boeckers TM, Meyer T, Winkler AS, Winkelman J, de Carvalho M, Thal DR, Otto M, Brännström T, Volk AE, Kursula P, Danzer KM, Lichtner P, Dikic I, Meitinger T, Ludolph AC, Strom TM, Andersen PM, Weishaupt JH
    (See online at https://doi.org/10.1038/nn.4000)
  • Impact of Charged Particle Exposure on Homologous DNA Double-Strand Break Repair in Human Blood-Derived Cells. Front Oncol. 2015 Nov 11;5:250
    Rall M, Kraft D, Volcic M, Cucu A, Nasonova E, Taucher-Scholz G, Bönig H, Wiesmüller L, Fournier C
    (See online at https://doi.org/10.3389/fonc.2015.00250)
  • In vivo characterization of human myofibrillar myopathy genes in zebrafish. Biochem Biophys Res Commun. 2015 May 29;461(2):217-23
    Bührdel JB, Hirth S, Kessler M, Westphal S, Forster M, Manta L, Wiche G, Schoser B, Schessl J, Schröder R, Clemen CS, Eichinger L, Fürst DO, van der Ven PF, Rottbauer W, Just S
    (See online at https://doi.org/10.1016/j.bbrc.2015.03.149)
  • Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area. Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1498-506
    Krabbe S, Duda J, Schiemann J, Poetschke C, Schneider G, Kandel ER, Liss B, Roeper J, Simpson EH
    (See online at https://doi.org/10.1073/pnas.1500450112)
  • Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels. Retrovirology. 2015 Oct 9;12:86
    Heigele A, Joas S, Regensburger K, Kirchhoff F
    (See online at https://doi.org/10.1186/s12977-015-0213-1)
  • Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish. Cell. 2015 Dec 3;163(6):1527-38
    Reichwald K, Petzold A, Koch P, Downie BR, Hartmann N, Pietsch S, Baumgart M, Chalopin D, Felder M, Bens M, Sahm A, Szafranski K, Taudien S, Groth M, Arisi I, Weise A, Bhatt SS, Sharma V, Kraus JM, Schmid F, Priebe S, Liehr T, Görlach M, Than ME, Hiller M, Kestler HA, Volff JN, Schartl M, Cellerino A, Englert C, Platzer M
    (See online at https://doi.org/10.1016/j.cell.2015.10.071)
  • Neuronal expression of the transcription factor serum response factor modulates myelination in a mouse multiple sclerosis model. Glia. 2015 Jun;63(6):958-76
    Anastasiadou S, Liebenehm S, Sinske D, Meyer zu Reckendorf C, Moepps B, Nordheim A, Knöll B
    (See online at https://doi.org/10.1002/glia.22794)
  • TDP-43 is intercellularly transmitted across axon terminals. J Cell Biol. 2015 Nov 23;211(4):897-911
    Feiler MS, Strobel B, Freischmidt A, Helferich AM, Kappel J, Brewer BM, Li D, Thal DR, Walther P, Ludolph AC, Danzer KM, Weishaupt JH
    (See online at https://doi.org/10.1083/jcb.201504057)
  • Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes. Acta Neuropathol. 2016 Mar;131(3):379-91
    Bliederhaeuser C, Grozdanov V, Speidel A, Zondler L, Ruf WP, Bayer H, Kiechle M, Feiler MS, Freischmidt A, Brenner D, Witting A, Hengerer B, Fändrich M, Ludolph AC, Weishaupt JH, Gillardon F, Danzer KM
    (See online at https://doi.org/10.1007/s00401-015-1504-2)
  • BiTrinA--multiscale binarization and trinarization with quality analysis. Bioinformatics. 2016 Feb 1;32(3):465-8
    Müssel C, Schmid F, Blätte TJ, Hopfensitz M, Lausser L, Kestler HA
    (See online at https://doi.org/10.1093/bioinformatics/btv591)
  • Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA network of neuroblastoma. Cancer Lett. 2016 Feb 1;371(1):79-89
    Dahlhaus M, Burkovski A, Hertwig F, Mussel C, Volland R, Fischer M, Debatin KM, Kestler HA, Beltinger C
    (See online at https://doi.org/10.1016/j.canlet.2015.11.025)
  • DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression. Proc Natl Acad Sci USA. 2016 Jul 26;113(30):E4311-9
    Hampp S, Kiessling T, Buechle K, Mansilla SF, Thomale J, Rall M, Ahn J, Pospiech H, Gottifredi V, Wiesmüller L
    (See online at https://doi.org/10.1073/pnas.1605828113)
  • Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination. Sci Rep. 2016 Jul 11;6:29419
    Stifter K, Schuster C, Schlosser M, Boehm BO, Schirmbeck R
    (See online at https://doi.org/10.1038/srep29419)
  • Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive. EBioMedicine. 2016 Oct;12:227-238
    Taudien S, Lausser L, Giamarellos-Bourboulis EJ, Sponholz C, Schöneweck F, Felder M, Schirra LR, Schmid F, Gogos C, Groth S, Petersen BS, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler HA, Platzer M
    (See online at https://doi.org/10.1016/j.ebiom.2016.08.037)
  • GiANT: gene set uncertainty in enrichment analysis. Bioinformatics. 2016 Jun 15;32(12):1891-4
    Schmid F, Schmid M, Müssel C, Sträng JE, Buske C, Bullinger L, Kraus JM, Kestler HA
    (See online at https://doi.org/10.1093/bioinformatics/btw030)
  • GPR56 contributes to the development of acute myeloid leukemia in mice. Leukemia. 2016 Aug;30(8):1734-41
    Daria D, Kirsten N, Muranyi A, Mulaw M, Ihme S, Kechter A, Hollnagel M, Bullinger L, Döhner K, Döhner H, Feuring-Buske M, Buske C
    (See online at https://doi.org/10.1038/leu.2016.76)
  • Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity. Cell Host Microbe. 2016 Apr 13;19(4):504-14
    Krapp C, Hotter D, Gawanbacht A, McLaren PJ, Kluge SF, Stürzel CM, Mack K, Reith E, Engelhart S, Ciuffi A, Hornung V, Sauter D, Telenti A, Kirchhoff F
    (See online at https://doi.org/10.1016/j.chom.2016.02.019)
  • Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. PLoS One. 2016 Mar 8;11(3):e0150323
    Hirth S, Bühler A, Bührdel JB, Rudeck S, Dahme T, Rottbauer W, Just S
    (See online at https://doi.org/10.1371/journal.pone.0150323)
  • Thioredoxin reductase inhibitor auranofin prevents membrane transport of diphtheria toxin into the cytosol and protects human cells from intoxication. Toxicon. 2016 Jun 15;116:23-8
    Schnell L, Dmochewitz-Kück L, Feigl P, Montecucco C, Barth H
    (See online at https://doi.org/10.1016/j.toxicon.2015.04.012)
  • Validation of a multiplexing technique to determine the intrathecal, polyspecific antiviral immune response in multiple sclerosis. Expert Rev Mol Diagn. 2016 Dec;16(12):1353-1356
    Huss A, Buttmann M, Brecht I, Weishaupt A, Otto M, Tumani H
    (See online at https://doi.org/10.1080/14737159.2016.1249468)
  • A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence. PLoS Comput Biol. 2017 Dec 4;13(12):e1005741
    Meyer P, Maity P, Burkovski A, Schwab J, Müssel C, Singh K, Ferreira FF, Krug L, Maier HJ, Wlaschek M, Wirth T, Kestler HA, Scharffetter-Kochanek K
    (See online at https://doi.org/10.1371/journal.pcbi.1005741)
  • An Epha4/Sipa1l3/Wnt pathway regulates eye development and lens maturation. Development. 2017 Jan 15;144(2):321-333
    Rothe M, Kanwal N, Dietmann P, Seigfried FA, Hempel A, Schütz D, Reim D, Engels R, Linnemann A, Schmeisser MJ, Bockmann J, Kühl M, Boeckers TM, Kühl SJ
    (See online at https://doi.org/10.1242/dev.147462)
  • Comparison of Sirtuin 3 Levels in ALS and Huntington's Disease-Differential Effects in Human Tissue Samples vs. Transgenic Mouse Models. Front Mol Neurosci. 2017 May 26;10:156
    Buck E, Bayer H, Lindenberg KS, Hanselmann J, Pasquarelli N, Ludolph AC, Weydt P, Witting A
    (See online at https://doi.org/10.3389/fnmol.2017.00156)
  • Complement C5a-Induced Changes in NeutrophilMorphology During Inflammation. Scand J Immunol. 2017 Sep;86(3):143-155
    Denk S, Taylor RP, Wiegner R, Cook EM, Lindorfer MA, Pfeiffer K, Paschke S, Eiseler T, Weiss M, Barth E, Lambris JD, Kalbitz M, Martin T, Barth H, MessererDAC, Gebhard F, Huber- Lang MS
    (See online at https://doi.org/10.1111/sji.12580)
  • Epithelial NEMO/IKKγ limits fibrosis and promotes regeneration during pancreatitis. Gut. 2017 Nov;66(11):1995-2007
    Chan LK, Gerstenlauer M, Konukiewitz B, Steiger K, Weichert W, Wirth T, Maier HJ
    (See online at https://doi.org/10.1136/gutjnl-2015-311028)
  • Frizzled 3 acts upstream of Alcam during embryonic eye development. Dev Biol. 2017 Jun 1;426(1):69-83
    Seigfried FA, Cizelsky W, Pfister AS, Dietmann P, Walther P, Kühl M, Kühl SJ
    (See online at https://doi.org/10.1016/j.ydbio.2017.04.004)
  • Generic wound signals initiate regeneration in missingtissue contexts. Nat Commun. 2017 Dec 22;8(1):2282
    Owlarn S, Klenner F, Schmidt D, Rabert F, Tomasso A, Reuter H, Mulaw MA, Moritz S, Gentile L, Weidinger G, Bartscherer K
    (See online at https://doi.org/10.1038/s41467-017-02338-x)
  • Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation. Leukemia. 2017 Nov;31(11):2491-2502
    Thiel VN, Giaimo BD, Schwarz P, Soller K, Vas V, Bartkuhn M, Blätte TJ, Döhner K, Bullinger L, Borggrefe T, Geiger H, Oswald F
    (See online at https://doi.org/10.1038/leu.2017.105)
  • Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells. Sci Rep. 2017 Jun 2;7(1):2724
    Ernst K, Schmid J, Beck M, Hägele M, Hohwieler M, Hauff P, Ückert AK, Anastasia A, Fauler M, Jank T, Aktories K, Popoff MR, Schiene-Fischer C, Kleger A, Müller M, Frick M, Barth H
    (See online at https://doi.org/10.1038/s41598-017-02882-y)
  • Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing. PLoS One. 2017 Jun 14;12(6):e0179512
    Bergdolt S, Kovtun A, Hägele Y, Liedert A, Schinke T, Amling M, Huber-Lang M, Ignatius A
    (See online at https://doi.org/10.1371/journal.pone.0179512)
  • Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. EMBO J. 2017 Apr 3;36(7):840-853. Erratum in: EMBO J. 2017 May 15;36(10):1463
    Guidi N, Sacma M, Ständker L, Soller K, Marka G, Eiwen K, Weiss JM, Kirchhoff F, Weil T, Cancelas JA, Florian MC, Geiger H
    (See online at https://doi.org/10.15252/embj.201694969)
  • Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation. PLoS Pathog. 2017 Aug 31;13(8):e1006598
    Hotter D, Krabbe T, Reith E, Gawanbacht A, Rahm N, Ayouba A, Van Driessche B, Van Lint C, Peeters M, Kirchhoff F, Sauter D
    (See online at https://doi.org/10.1371/journal.ppat.1006598)
  • Semen amyloids participate in spermatozoa selection and clearance. elife. 2017 Jun 27;6
    Roan NR, Sandi-Monroy N, Kohgadai N, Usmani SM, Hamil KG, Neidleman J, Montano M, Ständker L, Röcker A, Cavrois M, Rosen J, Marson K, Smith JF, Pilcher CD, Gagsteiger F, Sakk O, O'Rand M, Lishko PV, Kirchhoff F, Münch J, Greene WC
    (See online at https://doi.org/10.7554/eLife.24888.001)
  • Septin 6 regulates engraftment and lymphoid differentiation potential of murine long-term hematopoietic stem cells. Exp Hematol. 2017 Nov;55:45-55
    Senger K, Marka G, Soller K, Sakk V, Florian MC, Geiger H
    (See online at https://doi.org/10.1016/j.exphem.2017.07.005)
  • Stability of Signaling Pathways during Aging-A Boolean Network Approach. Biology (Basel). 2017 Dec 18;6(4)
    Schwab JD, Siegle L, Kühlwein SD, Kühl M, Kestler HA
    (See online at https://doi.org/10.3390/biology6040046)
  • The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells. Sci Rep. 2017 Apr 4;7(1):613
    Schuster M, Schnell L, Feigl P, Birkhofer C, Mohr K, Roeder M, Carle S, Langer S, Tippel F, Buchner J, Fischer G, Hausch F, Frick M, Schwan C, Aktories K, Schiene-Fischer C, Barth H
    (See online at https://doi.org/10.1038/s41598-017-00780-x)
  • The inflammatory phase of fracture healing is influenced by oestrogen status in mice. Eur J Med Res. 2017 Jul 6;22(1):23
    Haffner-Luntzer M, Fischer V, Prystaz K, Liedert A, Ignatius A
    (See online at https://doi.org/10.1186/s40001-017-0264-y)
  • ViSiBooL-visualization and simulation of Boolean networks with temporal constraints. Bioinformatics. 2017 Feb 15;33(4):601-604
    Schwab J, Burkovski A, Siegle L, Müssel C, Kestler HA
    (See online at https://doi.org/10.1093/bioinformatics/btw661)
  • Aged murine hematopoietic stem cells drive aging-associated immune remodeling. Blood. 2018 Aug 9;132(6):565-576
    Leins H, Mulaw M, Eiwen K, Sakk V, Liang Y, Denkinger M, Geiger H, Schirmbeck R
    (See online at https://doi.org/10.1182/blood-2018-02-831065)
  • Automatic Screening for Perturbations in Boolean Networks. Front Physiol. 2018 Apr 24;9:431
    Schwab JD, Kestler HA
    (See online at https://doi.org/10.3389/fphys.2018.00431)
  • Base excision repair proteins couple activationinduced cytidine deaminase and endonuclease G during replication stress-induced MLL destabilization. Leukemia. 2018 Jan;32(1):159-167
    Gole B, Mian E, Rall M, Wiesmüller L
    (See online at https://doi.org/10.1038/leu.2017.191)
  • Coincidence of lymphomatoid granulomatosis, chronic myelomonocytic leukemia, and anaplastic T cell lymphoma after methotrexate therapy for rheumatoid arthritis. Ann Hematol. 2019 Feb;98(2):515-517
    Dugge R, Kreipe H, Rosenwald A, Lehmann U, Möller P, Barth TFE, Erlemann R
    (See online at https://doi.org/10.1007/s00277-018-3434-2)
  • Comparison of Fatty Acid and Gene Profiles in Skeletal Muscle in Normal and Obese C57BL/6J Mice before and after Blunt Muscle Injury. Front Physiol. 2018 Jan 30;9:19
    Werner JU, Tödter K, Xu P, Lockhart L, Jähnert M, Gottmann P, Schürmann A, Scheja L, Wabitsch M, Knippschild U
    (See online at https://doi.org/10.3389/fphys.2018.00019)
  • Distinct Effects of IL-6 Classic and Trans- Signaling in Bone Fracture Healing. Am J Pathol. 2018 Feb;188(2):474-490
    Prystaz K, Kaiser K, Kovtun A, Haffner-Luntzer M, Fischer V, Rapp AE, Liedert A, Strauss G, Waetzig GH, Rose-John S, Ignatius A
    (See online at https://doi.org/10.1016/j.ajpath.2017.10.011)
  • Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia. J Clin Oncol. 2018 Apr 1;36(10):1007-1016
    Bhayadia R, Krowiorz K, Haetscher N, Jammal R, Emmrich S, Obulkasim A, Fiedler J, Schwarzer A, Rouhi A, Heuser M, Wingert S, Bothur S, Döhner K, Mätzig T, Ng M, Reinhardt D, Döhner H, Zwaan CM, van den Heuvel Eibrink M, Heckl D, Fornerod M, Thum T, Humphries RK, Rieger MA, Kuchenbauer F, Klusmann JH
    (See online at https://doi.org/10.1200/JCO.2017.75.2204)
  • FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL. Blood. 2019 Feb 21;133(8):830-839
    Close V, Close W, Kugler SJ, Reichenzeller M, Yosifov DY, Bloehdorn J, Pan L, Tausch E, Westhoff MA, Döhner H, Stilgenbauer S, Oswald F, Mertens D
    (See online at https://doi.org/10.1182/blood-2018-09-874529)
  • Fine-tuning of FOXO3A in cHL as a survival mechanism and a hallmark of abortive plasma cell differentiation. Blood. 2018 Apr 5;131(14):1556-1567
    Osswald CD, Xie L, Guan H, Herrmann F, Pick SM, Vogel MJ, Gehringer F, Chan FC, Steidl C, Wirth T, Ushmorov A
    (See online at https://doi.org/10.1182/blood-2017-07-795278)
  • Human Serum Albumin Is an Essential Component of the Host Defense Mechanism Against Clostridium difficile Intoxication. J Infect Dis. 2018 Sep 22;218(9):1424-1435
    di Masi A, Leboffe L, Polticelli F, Tonon F, Zennaro C, Caterino M, Stano P, Fischer S, Hägele M, Müller M, Kleger A, Papatheodorou P, Nocca G, Arcovito A, Gori A, Ruoppolo M, Barth H, Petrosillo N, Ascenzi P, Di Bella S
    (See online at https://doi.org/10.1093/infdis/jiy338)
  • IKK2/NF-κB signaling protects neurons after traumatic brain injury. FASEB J. 2018 Apr;32(4):1916 1932
    Mettang M, Reichel SN, Lattke M, Palmer A, Abaei A, Rasche V, Huber-Lang M, Baumann B, Wirth T
    (See online at https://doi.org/10.1096/fj.201700826R)
  • IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia. Blood. 2018 Oct 11;132(15):1614-1617
    Alsadeq A, Lenk L, Vadakumchery A, Cousins A, Vokuhl C, Khadour A, Vogiatzi F, Seyfried F, Meyer LH, Cario G, Hobeika E, Debatin KM, Halsey C, Schrappe M, Schewe DM, Jumaa H
    (See online at https://doi.org/10.1182/blood-2018-04-844209)
  • Induced global deletion of glucocorticoid receptor impairs fracture healing. FASEB J. 2018 Apr;32(4):2235-2245
    Rapp AE, Hachemi Y, Kemmler J, Koenen M, Tuckermann J, Ignatius A
    (See online at https://doi.org/10.1096/fj.201700459RR)
  • inelli P, Radermacher P, Wanner GA, Simmen HP, Gebhard F, Rittirsch D, Huber-Lang M. Hemorrhagic shock drives glycocalyx, barrier and organ dysfunction early after polytrauma. J Crit Care. 2018 Apr;44:229-237
    Halbgebauer R, Braun CK, Denk S, Mayer B, Cinelli P, Radermacher P, Wanner GA, Simmen HP, Gebhard F, Rittirsch D, Huber-Lang M
    (See online at https://doi.org/10.1016/j.jcrc.2017.11.025)
  • LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome Biol. 2018 Nov 7;19(1):189
    Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, Vollmer A, Markaki Y, Leonhardt H, Buske C, Lipka DB, Plass C, Zheng Y, Mulaw MA, Geiger H, Florian MC
    (See online at https://doi.org/10.1186/s13059-018-1557-3)
  • Loss of Proteostasis Is a Pathomechanism in Cockayne Syndrome. Cell Rep. 2018 May 8;23(6):1612-1619
    Alupei MC, Maity P, Esser PR, Krikki I, Tuorto F, Parlato R, Penzo M, Schelling A, Laugel V, Montanaro L, Scharffetter-Kochanek K, Iben S
    (See online at https://doi.org/10.1016/j.celrep.2018.04.041)
  • Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo. Autophagy. 2018;14(11):1911-1927
    Kustermann M, Manta L, Paone C, Kustermann J, Lausser L, Wiesner C, Eichinger L, Clemen CS, Schröder R, Kestler HA, Sandri M, Rottbauer W, Just S
    (See online at https://doi.org/10.1080/15548627.2018.1491491)
  • Neuroinflammation after Traumatic Brain Injury Is Enhanced in Activating Transcription Factor 3 Mutant Mice. J Neurotrauma. 2018 Oct 1;35(19):2317-2329
    Förstner P, Rehman R, Anastasiadou S, Haffner-Luntzer M, Sinske D, Ignatius A, Roselli F, Knöll B
    (See online at https://doi.org/10.1089/neu.2017.5593)
  • Neuroprotective effect of acute ethanol intoxication in TBI is associated to the hierarchical modulation of early transcriptional responses. Exp Neurol. 2018 Apr;302:34-45
    Chandrasekar A, Aksan B, Heuvel FO, Förstner P, Sinske D, Rehman R, Palmer A, Ludolph A, Huber-Lang M, Böckers T, Mauceri D, Knöll B, Roselli F
    (See online at https://doi.org/10.1016/j.expneurol.2017.12.017)
  • NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS. EMBO J. 2018 Aug 15;37(16)
    Ouali Alami N, Schurr C, Olde Heuvel F, Tang L, Li Q, Tasdogan A, Kimbara A, Nettekoven M, Ottaviani G, Raposo C, Röver S, Rogers-Evans M, Rothenhäusler B, Ullmer C, Fingerle J, Grether U, Knuesel I, Boeckers TM, Ludolph A, Wirth T, Roselli F, Baumann B
    (See online at https://doi.org/10.15252/embj.201798697)
  • Physical basis of amyloid fibril polymorphism. Nat Commun. 2018 Feb 16;9(1):699
    Close W, Neumann M, Schmidt A, Hora M, Annamalai K, Schmidt M, Reif B, Schmidt V, Grigorieff N, Fändrich M
    (See online at https://doi.org/10.1038/s41467-018-03164-5)
  • PKD regulates actin polymerization, neutrophil deformability, and transendothelial migration in response to fMLP and trauma. J Leukoc Biol. 2018 Sep;104(3):615-630
    Wille C, Eiseler T, Langenberger ST, Richter J, Mizuno K, Radermacher P, Knippschild U, Huber-Lang M, Seufferlein T, Paschke S
    (See online at https://doi.org/10.1002/JLB.4A0617-251RR)
  • Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo. Arch Toxicol. 2018 Jan;92(1):323-336
    Martin T, Möglich A, Felix I, Förtsch C, Rittlinger A, Palmer A, Denk S, Schneider J, Notbohm L, Vogel M, Geiger H, Paschke S, Huber-Lang M, Barth H
    (See online at https://doi.org/10.1007/s00204-017-2058-y)
  • Role of Hemorrhagic Shock in Experimental Polytrauma. Shock. 2018 Feb;49(2):154-163
    Denk S, Weckbach S, Eisele P, Braun CK, Wiegner R, Ohmann JJ, Wrba L, Hoenes FM, Kellermann P, Radermacher P, Wachter U, Hafner S, McCook O, Schultze A, Palmer A, Braumüller S, Gebhard F, Huber-Lang M
    (See online at https://doi.org/10.1097/SHK.0000000000000925)
  • Semantic Multi-Classifier Systems Identify Predictive Processes in Heart Failure Models across Species. Biomolecules. 2018 Nov 26;8(4)
    Lausser L, Siegle L, Rottbauer W, Frank D, Just S, Kestler HA
    (See online at https://doi.org/10.3390/biom8040158)
  • Semen inhibits Zika virus infection of cells and tissues from the anogenital region. Nat Commun. 2018 Jun 7;9(1):2207
    Müller JA, Harms M, Krüger F, Groß R, Joas S, Hayn M, Dietz AN, Lippold S, von Einem J, Schubert A, Michel M, Mayer B, Cortese M, Jang KS, Sandi-Monroy N, Deniz M, Ebner F, Vapalahti O, Otto M, Bartenschlager R, Herbeuval JP, Schmidt-Chanasit J, Roan NR, Münch J
    (See online at https://doi.org/10.1038/s41467-018-04442-y)
  • Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development. Nat Commun. 2018 Dec 6;9(1):5218
    Reisser M, Palmer A, Popp AP, Jahn C, Weidinger G, Gebhardt JCM
    (See online at https://doi.org/10.1038/s41467-018-07731-8)
  • Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity. Nat Commun. 2018 Apr 10;9(1):1371
    Joas S, Parrish EH, Gnanadurai CW, Lump E, Stürzel CM, Parrish NF, Learn GH, Sauermann U, Neumann B, Rensing KM, Fuchs D, Billingsley JM, Bosinger SE, Silvestri G, Apetrei C, Huot N, Garcia-Tellez T, Müller-Trutwin M, Hotter D, Sauter D, Stahl-Hennig C, Hahn BH, Kirchhoff F
    (See online at https://doi.org/10.1038/s41467-018-03762-3)
  • Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9. elife. 2018 Aug 23;7
    Commisso B, Ding L, Varadi K, Gorges M, Bayer D, Boeckers TM, Ludolph AC, Kassubek J, Müller OJ, Roselli F
    (See online at https://doi.org/10.7554/eLife.36892.001)
  • Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia. Blood. 2018 Jun 28;131(26):2929-2942
    Wang F, Demir S, Gehringer F, Osswald CD, Seyfried F, Enzenmüller S, Eckhoff SM, Maier T, Holzmann K, Debatin KM, Wirth T, Meyer LH, Ushmorov A
    (See online at https://doi.org/10.1182/blood-2017-10-813576)
  • A miR-29a-driven negative feedback loop regulates peripheral glucocorticoid receptor signaling. FASEB J. 2019 May;33(5):5924-5941
    Glantschnig C, Koenen M, Gil-Lozano M, Karbiener M, Pickrahn I, Williams-Dautovich J, Patel R, Cummins CL, Giroud M, Hartleben G, Vogl E, Blüher M, Tuckermann J, Uhlenhaut H, Herzig S, Scheideler M
    (See online at https://doi.org/10.1096/fj.201801385RR)
  • Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via β-AR signaling. Proc Natl Acad Sci USA. 2019 Apr 23;116(17):8615-8622
    Haffner-Luntzer M, Foertsch S, Fischer V, Prystaz K, Tschaffon M, Mödinger Y, Bahney CS, Marcucio RS, Miclau T, Ignatius A, Reber SO
    (See online at https://doi.org/10.1073/pnas.1819218116)
  • Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation. Nat Commun. 2019 May 2;10(1):2031
    Cocciardi S, Dolnik A, Kapp-Schwoerer S, Rücker FG, Lux S, Blätte TJ, Skambraks S, Krönke J, Heidel FH, Schnöder TM, Corbacioglu A, Gaidzik VI, Paschka P, Teleanu V, Göhring G, Thol F, Heuser M, Ganser A, Weber D, Sträng E, Kestler HA, Döhner H, Bullinger L, Döhner K
    (See online at https://doi.org/10.1038/s41467-019-09745-2)
  • Effects of Psychosocial Stress on Subsequent Hemorrhagic Shock and Resuscitation in Male Mice. Shock. 2019 Jun;51(6):725-730
    Langgartner D, Wachter U, Hartmann C, Gröger M, Vogt J, Merz T, McCook O, Fink M, Kress S, Georgieff M, Kunze JF, Radermacher PL, Reber SO, Wepler M
    (See online at https://doi.org/10.1097/shk.0000000000001204)
  • getITD for FLT3-ITD-based MRD monitoring in AML. Leukemia. 2019 May 14
    Blätte TJ, Schmalbrock LK, Skambraks S, Lux S, Cocciardi S, Dolnik A, Döhner H, Döhner K, Bullinger L
    (See online at https://doi.org/10.1038/s41375-019-0483-z)
  • Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins. Cell Rep. 2019 May 14;27(7):2092-2104.e10
    Braun E, Hotter D, Koepke L, Zech F, Groß R, Sparrer KMJ, Müller JA, Pfaller CK, Heusinger E, Wombacher R, Sutter K, Dittmer U, Winkler M, Simmons G, Jakobsen MR, Conzelmann KK, Pöhlmann S, Münch J, Fackler OT, Kirchhoff F, Sauter D
    (See online at https://doi.org/10.1016/j.celrep.2019.04.063)
  • HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses. elife. 2019 Feb 5;8. pii: e41930
    Langer S, Hammer C, Hopfensperger K, Klein L, Hotter D, De Jesus PD, Herbert KM, Pache L, Smith N, van der Merwe JA, Chanda SK, Fellay J, Kirchhoff F, Sauter D
    (See online at https://doi.org/10.7554/eLife.41930.001)
  • IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation. Cell Host Microbe. 2019 Jun 12;25(6):858-872.e13
    Hotter D, Bosso M, Jønsson KL, Krapp C, Stürzel CM, Das A, Littwitz-Salomon E, Berkhout B, Russ A, Wittmann S, Gramberg T, Zheng Y, Martins LJ, Planelles V, Jakobsen MR, Hahn BH, Dittmer U, Sauter D, Kirchhoff F
    (See online at https://doi.org/10.1016/j.chom.2019.05.002)
  • IL-13 Impairs Tight Junctions in Airway Epithelia. Int J Mol Sci. 2019 Jun 30;20(13)
    Schmidt H, Braubach P, Schilpp C, Lochbaum R, Neuland K, Thompson K, Jonigk D, Frick M, Dietl P, Wittekindt OH
    (See online at https://doi.org/10.3390/ijms20133222)
  • Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases. Front Mol Neurosci. 2019 Apr 26;12:106
    Kreiner G, Sönmez A, Liss B, Parlato R
    (See online at https://doi.org/10.3389/fnmol.2019.00106)
  • MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo. Stem Cells Int. 2019 Jun 2;2019:8475389
    Walter K, Tiwary K, Trajkovic-Arsic M, Hidalgo-Sastre A, Dierichs L, Liffers ST, Gu J, Gout J, Schulte LA, Münch J, Seufferlein T, Sainz B Jr, Siveke JT, Rodriguez-Aznar E, Hermann PC
    (See online at https://doi.org/10.1155/2019/8475389)
  • Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish. Commun Biol. 2019 Jan 29;2:31
    Maerz LD, Burkhalter MD, Schilpp C, Wittekindt OH, Frick M, Philipp M
    (See online at https://doi.org/10.1038/s42003-018-0272-7)
  • Reduced Terminal Complement Complex Formation in Mice Manifests in Low Bone Mass and Impaired Fracture Healing. Am J Pathol. 2019 Jan;189(1):147-161
    Mödinger Y, Rapp AE, Vikman A, Ren Z, Fischer V, Bergdolt S, Haffner-Luntzer M, Song WC, Lambris JD, Huber-Lang M, Neidlinger-Wilke C, Brenner RE, Ignatius A
    (See online at https://doi.org/10.1016/j.ajpath.2018.09.011)
  • Representing dynamic biological networks with multi-scale probabilistic models. Commun Biol. 2019 Jan 17;2:21
    Groß A, Kracher B, Kraus JM, Kühlwein SD, Pfister AS, Wiese S, Luckert K, Pötz O, Joos T, Van Daele D, De Raedt L, Kühl M, Kestler HA
    (See online at https://doi.org/10.1038/s42003-018-0268-3)
  • Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation. Autophagy. 2019 Apr 2:1-19
    Catanese A, Olde Heuvel F, Mulaw M, Demestre M, Higelin J, Barbi G, Freischmidt A, Weishaupt JH, Ludolph AC, Roselli F, Boeckers TM
    (See online at https://doi.org/10.1080/15548627.2019.1589257)
  • Single-molecule imaging of the transcription factor SRF reveals prolonged chromatin-binding kinetics upon cell stimulation. Proc Natl Acad Sci USA. 2019 Jan 15;116(3):880-889
    Hipp L, Beer J, Kuchler O, Reisser M, Sinske D, Michaelis J, Gebhardt JCM, Knöll B
    (See online at https://doi.org/10.1073/pnas.1812734116)
  • Storage-Dependent Generation of Potent Anti-ZIKV Activity in Human Breast Milk. Viruses. 2019 Jun 28;11(7)
    Conzelmann C, Zou M, Groß R, Harms M, Röcker A, Riedel CU, Münch J, Müller JA
    (See online at https://doi.org/10.3390/v11070591)
  • Supramolecular Toxin Complexes for Targeted Pharmacological Modulation of Polymorphonuclear Leukocyte Functions. Adv Healthc Mater. 2019 Jul 18:e1900665
    Heck AJ, Ostertag T, Schnell L, Fischer S, Agrawalla BK, Winterwerber P, Wirsching E, Fauler M, Frick M, Kuan SL, Weil T, Barth H
    (See online at https://doi.org/10.1002/adhm.201900665)
 
 

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