Molekulare Mechanismen synaptischer Plastizität bei chronischem Schmerz

• Antragstellerin: Professorin Dr. Rohini Kuner
• Fachliche Zuordnung: Pharmakologie
• Förderung: Förderung von 2001 bis 2006
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5329410

• Erstellungsjahr: 2008

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Characterization of the expression of PDZ-RhoGEF, LARG and Galpha12/Galpha13 proteins in the murine nervous system. Eur J Neurosci., 16(12):2333-41, 2002
  Kuner R, Swiercz JM, Zywietz A, Tappe A, Offermanns S
  
• Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron, 35(1):51-63, 2002
  Swiercz JM, Kuner R, Behrens J, Offermanns S
  
• Spinal upregulation of the nitric oxide synthase-interacting protein NOSIP in a rat model of inflammatory pain, Neurosci. Lett., 350(1):13-16, 2003
  Dreyer J, Hirlinger D, Müller-Esterl W, Oess S, Kuner R
  
• (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity, J. Neurosci., 24(46): 10454-10465 2004
  Dreyer J, Schleicher M, Tappe A, Schilling K, Kuner T, Kusumawidijaja G, Müller-Esterl W, Oess S and Kuner R
  
• Conditional gene targeting in neurons of the dorsal root ganglia and trigeminal ganglia, Genesis, 38/3: 122-129, 2004
  Agarwal N., Offermanns S. and Kuner R.
  
• Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: A anatomical basis for morphogenetic effects of Sema4D during development, Eur J Neurosci., 19(10): 2622-32, 2004
  Worzfeld T., Püschel A., Offermanns S., Kuner R.
  
• Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2. J.Cell Biol., 65(6): 869-80, 2004
  Swiercz J.M., Kuner R. & Offermanns S.
  
• The AMPA receptor subunits, GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain, Neuron, 44(4): 637-50, 2004
  Hartmann B., Ahmadi S., Heppenstall P., Zeilhofer H.U., Lewin G., Schott C., Seeburg P.H., Sprengel R. & Kuner R.
  
• Late-onset motoneuron disease caused by transgenic expression of a functionally modified AMPA receptor subunit, Proc Natl Acad Sci USA. 102(16):5826-31, 2005
  Kuner R., Groom A., Bresink I., Kornau H.C., Stefovska V., Müller G., Hartmann B., Tschauner K., Waibel S., Ludolph A.C., Ikonomidou C., Seeburg P.H. & Turski L.
  
• Regulation of motor performance and striatal function by synaptic scaffolding proteins of the Homer1 family. Proc Natl Acad Sci USA; 103: 774-9, 2006
  Tappe A, Kuner R
  
• Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain. Nature Medicine, 12: 677-81, 2006
  Tappe A, Klugmann M, Luo C, Hirlinger D, Agarwal N, Benrath J, Ehrengruber MU, During MJ, Kuner R
  
• Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci U S A. 104(2):660-5, 2007
  Pareek TK, Keller J, Kesavapany S, Agarwal N, Kuner R, Pant HC, Iadarola MJ, Brady RO, Kulkarni AB
  
• Nociceptor-specific conditional gene deletion reveals that cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors. Nature Neuroscience; 10: 870-9, 2007
  Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin C, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R
  
• Activity-dependent potentiation of calcium signals in spinal sensory networks in inflammatory pain states. Pain, Oct 14. Epub ahead of print, 2008
  Luo, C., Seeburg, P. H., Sprengel, R. and Kuner, R.
  
• Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors. J Neurosci, 28: 125-32, 2008
  Liu Y, Yang FC, Okuda T, Dong X, Zylka MJ, Chen CL, Anderson DJ, Kuner R, Ma Q