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Molekulare Mechanismen synaptischer Plastizität bei chronischem Schmerz

Subject Area Pharmacology
Term from 2001 to 2006
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 5329410
 
Final Report Year 2008

Final Report Abstract

No abstract available

Publications

  • Characterization of the expression of PDZ-RhoGEF, LARG and Galpha12/Galpha13 proteins in the murine nervous system. Eur J Neurosci., 16(12):2333-41, 2002
    Kuner R, Swiercz JM, Zywietz A, Tappe A, Offermanns S
  • Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron, 35(1):51-63, 2002
    Swiercz JM, Kuner R, Behrens J, Offermanns S
  • Spinal upregulation of the nitric oxide synthase-interacting protein NOSIP in a rat model of inflammatory pain, Neurosci. Lett., 350(1):13-16, 2003
    Dreyer J, Hirlinger D, Müller-Esterl W, Oess S, Kuner R
  • (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity, J. Neurosci., 24(46): 10454-10465 2004
    Dreyer J, Schleicher M, Tappe A, Schilling K, Kuner T, Kusumawidijaja G, Müller-Esterl W, Oess S and Kuner R
  • Conditional gene targeting in neurons of the dorsal root ganglia and trigeminal ganglia, Genesis, 38/3: 122-129, 2004
    Agarwal N., Offermanns S. and Kuner R.
  • Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: A anatomical basis for morphogenetic effects of Sema4D during development, Eur J Neurosci., 19(10): 2622-32, 2004
    Worzfeld T., Püschel A., Offermanns S., Kuner R.
  • Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2. J.Cell Biol., 65(6): 869-80, 2004
    Swiercz J.M., Kuner R. & Offermanns S.
  • The AMPA receptor subunits, GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain, Neuron, 44(4): 637-50, 2004
    Hartmann B., Ahmadi S., Heppenstall P., Zeilhofer H.U., Lewin G., Schott C., Seeburg P.H., Sprengel R. & Kuner R.
  • Late-onset motoneuron disease caused by transgenic expression of a functionally modified AMPA receptor subunit, Proc Natl Acad Sci USA. 102(16):5826-31, 2005
    Kuner R., Groom A., Bresink I., Kornau H.C., Stefovska V., Müller G., Hartmann B., Tschauner K., Waibel S., Ludolph A.C., Ikonomidou C., Seeburg P.H. & Turski L.
  • Regulation of motor performance and striatal function by synaptic scaffolding proteins of the Homer1 family. Proc Natl Acad Sci USA; 103: 774-9, 2006
    Tappe A, Kuner R
  • Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain. Nature Medicine, 12: 677-81, 2006
    Tappe A, Klugmann M, Luo C, Hirlinger D, Agarwal N, Benrath J, Ehrengruber MU, During MJ, Kuner R
  • Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci U S A. 104(2):660-5, 2007
    Pareek TK, Keller J, Kesavapany S, Agarwal N, Kuner R, Pant HC, Iadarola MJ, Brady RO, Kulkarni AB
  • Nociceptor-specific conditional gene deletion reveals that cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors. Nature Neuroscience; 10: 870-9, 2007
    Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin C, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R
  • Activity-dependent potentiation of calcium signals in spinal sensory networks in inflammatory pain states. Pain, Oct 14. Epub ahead of print, 2008
    Luo, C., Seeburg, P. H., Sprengel, R. and Kuner, R.
  • Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors. J Neurosci, 28: 125-32, 2008
    Liu Y, Yang FC, Okuda T, Dong X, Zylka MJ, Chen CL, Anderson DJ, Kuner R, Ma Q
 
 

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