Prenatal therapy of CDH using for tracheal occlusion absorbable biological material

• Applicant: Dr. Enrico Danzer
• Subject Area: Pediatric and Adolescent Medicine
• Term: from 2001 to 2004
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5352441

• Final Report Year: 2007

No abstract available

Publications

• In utero tracheal occlusion in fetal lambs downregulates pulmonary surfactant protein and mRNA expression in a thyroid transcription factor 1 related pathway. 2005 Pediatric Academic Societies' Meeting Washington, USA, 14th-17th May 2005
  E. Danzer, M.G. Davey, L. Robinson, N.S. Adzick, A.W. Flake, H.L. Hedrick
  
• Retinoic acid induced myelomeningocele in fetal rats: characterization by histopathology and magnetic resonance imaging. Exp Neurol 194(2): 467-475, 2005
  E. Danzer, U. Schwarz, S. Wehrli, A. Radu, N.S. Adzick, A.W. Flake
  
• Fetal tracheal occlusion in patients with severe congenital diaphragmatic hernia: a morphologic study of lung architecture and arterial muscularization. 37th Annual meeting of the American Pediatric Surgery Association, Hilton Head, USA, 21st-24th May, 2006
  E. Danzer, M.G. Davey, P. Kreiger, E.D. Ruchelli, M.P. Johnson, N.S. Adzick, A.W. Flake, H.L. Hedrick
  
• Normal neuromuscular development of the lower gastrointestinal tract and anorectum in fetal rats with retinoic acid induced myelomeningocele - implications for fetal surgery. Neuroscience Letters
  E. Danzer, A, Radu, L.E. Robinson, M.V. Volpe, N.S. Adzick, A.W. Flake
  
• Prenatal glucocorticoids and exogenous surfactant therapy improve postnatal lung function in lambs with severe diaphragmatic hernia following prenatal tracheal occlusion. Fed Res 60(2): 131-135, 2006
  M.G. Davey, E. Danzer, U. Schwarz, N.S Adzick, A.W. Flake, H.L. Hedrick
  
• Prenatal glucocorticoids improves lung morphometry and partially restores surfactant mRNA expression in lambs with diaphragmatic hernia undergoing fetal tracheal occlusion. Pediatr Pulmol 41 (12): 1188-1196,2006
  M.G. Davey, E. Danzer, U. Schwarz, N.S Adzick, A.W. Flake, H.L. Hedrick
  
• Pulmonary artery muscularization is reduced by fetal glucocorticoids in lambs with diaphragmatic hernia following tracheal occlusion. Am J Obstet Gynecol, 2006
  M.G. Davey, S. Shegu, E. Danzer, E. Ruchelli, N.S. Adzick, A.W. Flake, H.L. Hedrick
  
• Tracheal occlusion in fetal rats alters expression of mesenchymal nuclear transcription factors without affecting surfactant protein expression. J Pediatr Surg 41(4): 774-780, 2006
  E. Danzer, L.E. Robinson, M.G. Davey, U. Schwarz, M.A. Volpe, N.S. Adzick, A.W. Flake, H.L. Hedrick
  
• Structural and functional characterization of bladder smooth muscle in fetal rats with retinoic acid induced myelomeningocele. Am J Physiol Renal Physiol 292 (1): F197-F206,2007
  E. Danzer, D. Kiddoo, R.A. Redden, L. Robinson, A. Radu, S.A. Zderic, E.J. Doolin, N.S. Adzick, A.W. Flake