Identifizierung von sekretierten Faktoren des suprachiasmatischen Nukleus (SCN), welche circadiane Rhythmen lokomotorischer Aktivität in Säugern steuern

• Antragsteller: Professor Dr. Achim Kramer
• Fachliche Zuordnung: Neurowissenschaften
• Förderung: Förderung von 2002 bis 2006
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5363286

• Erstellungsjahr: 2010

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2004) A model of the mammalian circadian oscillator including the REV-ERBalpha module. Genome Informatics, Vol. 15. 2004, No. 1, pp. 3-12.
  Becker-Weimann S., Wolf J., Kramer A., Herzel H.
  
• (2004) Modeling feedback loops of the mammalian circadian oscillator. Biophysical Journal, Vol. 87. 2004, Issue 5, pp. 3023–3034.
  Becker-Weimann S, Wolf J, Herzel H, Kramer A
  
• (2004) Peroxisomal membrane proteins contain common Pexl9p-binding sites that are an integral part of their targeting signals. Molecular Biology of the Cell, Vol. 15. 2004, no. 7, pp. 3406-3417.
  Rottensteiner H., Kramer A., Lorenzen S., Stein K., Landgraf C., Volkmer-Engert R., Erdmann R.
  
• (2005) Entrainment in a model of the mammalian circadian oscillator. Journal of Biological Rhythms, Vol. 20. 2005, no. 1, pp. 83-93.
  Geier F., Becker-Weimann S., Kramer A., Herzel H.
  
• (2005) Mapping of phosphorylation sites by a multi-protease approach with highly specific phosphopeptide enrichment and nanoLC-MS/MS analysis. Analytical Chemistry, Vol. 77. 2005, Issue 16, pp. 5243–5250.
  Schlosser A., Vanselow J., Kramer A.
  
• (2005) Spontaneous synchronisation of coupled circadian oscillators. Biophysical Journal, Vol. 89. 2005, Issue 1, pp. 120–129.
  Gonze D., Bemard S., Waltermann C., Kramer A., Herzel H.
  
• (2006) Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes & Development, Vol. 20. 2006, Issue 19, pp. 2660-2672.
  Vanselow K., Vanselow J.T., Westermark P.O., ReischI S., Maier B., Korte T., Herrmann A., Herzel H., Schlosser A., Kramer A.
  
• (2006) Molecular basis for the binding polyspecific ity of an anti-cholera toxin peptide 3 monoclonal antibody. Journal of Molecular Recognition, Vol.19. 2006, Issue 1, pp. 49–59.
  Otte L., Knaute T., Schneider-Mergener J., Kramer A.
  
• (2007) Comprehensive phosphorylation site analysis of individual phosphoproteins applying scoring schemes for MS/MS data. Analytical Chemistry, Vol. 79. 2007, Issue 19, pp. 7439–7449.
  Schlosser A., Vanselow J., Kramer A.
  
• (2007) Promoter analysis of mammalian clock controlled genes. Genome Informatics, Vol. 18.2007, pp. 65-74.
  Bozek K., Kielbasa S.M., Kramer A., Herzel H.
  
• (2007) Structure of an anti-cholera toxin antibody Fab in complex with an epitopederived D-peptide: a case of polyspecific recognition. Journal of Molecular Recognition, Vol. 20. 2007, Issue 4, pp. 263–274.
  Scheerer P., Kramer A., Otte L., Seifert M., Wessner H., Scholz C., Krauß N., Schneider-Mergener J., Höhne W.
  
• (2008) Global parameter search reveals design principles of the mammalian circadian clock. BMC Systems Biology, Vol. 2.2008,:22.
  Locke J.C.W., Westermark P.O., Kramer A., Herzel H.
  
• (2008) Molecular insights into human daily behaviour. Proceedings of the National Academy of Sciences of the USA, Vol. 105 no. 5, pp. 1602–1607.
  Brown S.A., Kunz D., Dumas A., Westermark P.O., Vanselow K,. Tilmann-Wahnschaffe A., Herzel H., Kramer A.
  
• (2009) A circadian clock in macrophages controls inflammatory immune responses. Proceedings of the National Academy of Sciences of the United States of America (PNAS), vol. 106.2009, no. 50, pp. 21407–21412.
  Keller M., Mazuch J., Abraham U., Eom G.D., Herzog E.D., Volk H.D., Kramer A., Maier B.
  
• (2009) A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock. Genes & Development, Vol. 23. 2009, pp. 708-718.
  Maier B., Wendt S., Vanselow J.T., Wallach T., ReischI S., Oehmke S., Schlosser A., Kramer A.
  
• (2009) Biochemical evidence for a timing mechanism in Prochlorococcus. Journal of Bacteriology, Vol. 191. 2009, no. 17, pp. 5342-5347.
  Axmann I.M., Dühring U., Seeliger L., Amold A., Vanselow J.T., Kramer A., Wilde A.
  
• (2009) Regulation of clock controlled genes in mammals. PLoS ONE, Vol. 4.2009, Issue 3: e4882.
  Bozek K., Kielbasa S.M., Relogio A., Heine M., Dame C., Kramer A., Herzel H.
  
• (2009) Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2. PLoS Biology, Vol. 7.2009, Issue 4: e1000094.
  Hennig S., Strauss H.M., Vanselow K., Yildiz Ö., Schulze S., Arens J., Kramer A., Wolf E.