Identifizierung von sekretierten Faktoren des suprachiasmatischen Nukleus (SCN), welche circadiane Rhythmen lokomotorischer Aktivität in Säugern steuern

• Applicant: Professor Dr. Achim Kramer
• Subject Area: Neurosciences
• Term: from 2002 to 2006
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5363286

• Final Report Year: 2010

No abstract available

Publications

• (2004) A model of the mammalian circadian oscillator including the REV-ERBalpha module. Genome Informatics, Vol. 15. 2004, No. 1, pp. 3-12.
  Becker-Weimann S., Wolf J., Kramer A., Herzel H.
  
• (2004) Modeling feedback loops of the mammalian circadian oscillator. Biophysical Journal, Vol. 87. 2004, Issue 5, pp. 3023–3034.
  Becker-Weimann, Sabine; Wolf, Jana; Herzel, Hanspeter & Kramer, Achim
  
• (2004) Peroxisomal membrane proteins contain common Pexl9p-binding sites that are an integral part of their targeting signals. Molecular Biology of the Cell, Vol. 15. 2004, no. 7, pp. 3406-3417.
  Rottensteiner, Hanspeter; Kramer, Achim; Lorenzen, Stephan; Stein, Katharina; Landgraf, Christiane; Volkmer-Engert, Rudolf & Erdmann, Ralf
  
• (2005) Entrainment in a model of the mammalian circadian oscillator. Journal of Biological Rhythms, Vol. 20. 2005, no. 1, pp. 83-93.
  Geier, Florian; Becker-Weimann, Sabine; Kramer, Achim & Herzel, Hanspeter
  
• (2005) Mapping of phosphorylation sites by a multi-protease approach with highly specific phosphopeptide enrichment and nanoLC-MS/MS analysis. Analytical Chemistry, Vol. 77. 2005, Issue 16, pp. 5243–5250.
  Schlosser, Andreas; Vanselow, Jens T. & Kramer, Achim
  
• (2005) Spontaneous synchronisation of coupled circadian oscillators. Biophysical Journal, Vol. 89. 2005, Issue 1, pp. 120–129.
  Gonze, Didier; Bernard, Samuel; Waltermann, Christian; Kramer, Achim & Herzel, Hanspeter
  
• (2006) Molecular basis for the binding polyspecific ity of an anti-cholera toxin peptide 3 monoclonal antibody. Journal of Molecular Recognition, Vol.19. 2006, Issue 1, pp. 49–59.
  Otte, Livia; Knaute, Tobias; Schneider‐Mergener, Jens & Kramer, Achim
  
• (2006) Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes & Development, Vol. 20. 2006, Issue 19, pp. 2660-2672.
  Vanselow, Katja; Vanselow, Jens T.; Westermark, Pål O.; Reischl, Silke; Maier, Bert; Korte, Thomas; Herrmann, Andreas; Herzel, Hanspeter; Schlosser, Andreas & Kramer, Achim
  
• (2007) Comprehensive phosphorylation site analysis of individual phosphoproteins applying scoring schemes for MS/MS data. Analytical Chemistry, Vol. 79. 2007, Issue 19, pp. 7439–7449.
  Schlosser, Andreas; Vanselow, Jens T. & Kramer, Achim
  
• (2007) Promoter analysis of mammalian clock controlled genes. Genome Informatics, Vol. 18.2007, pp. 65-74.
  Bozek K., Kielbasa S.M., Kramer A., Herzel H.
  
• (2007) Structure of an anti-cholera toxin antibody Fab in complex with an epitopederived D-peptide: a case of polyspecific recognition. Journal of Molecular Recognition, Vol. 20. 2007, Issue 4, pp. 263–274.
  Scheerer, Patrick; Kramer, Achim; Otte, Livia; Seifert, Martina; Wessner, Helga; Scholz, Christa; Krauß, Norbert; Schneider‐Mergener, Jens & Höhne, Wolfgang
  
• (2008) Global parameter search reveals design principles of the mammalian circadian clock. BMC Systems Biology, Vol. 2.2008,:22.
  Locke, James CW; Westermark, Pål O; Kramer, Achim & Herzel, Hanspeter
  
• (2008) Molecular insights into human daily behaviour. Proceedings of the National Academy of Sciences of the USA, Vol. 105 no. 5, pp. 1602–1607.
  Brown, Steven A.; Kunz, Dieter; Dumas, Amelie; Westermark, Pål O.; Vanselow, Katja; Tilmann-Wahnschaffe, Amely; Herzel, Hanspeter & Kramer, Achim
  
• (2009) A circadian clock in macrophages controls inflammatory immune responses. Proceedings of the National Academy of Sciences of the United States of America (PNAS), vol. 106.2009, no. 50, pp. 21407–21412.
  Keller, Maren; Mazuch, Jeannine; Abraham, Ute; Eom, Gina D.; Herzog, Erik D.; Volk, Hans-Dieter; Kramer, Achim & Maier, Bert
  
• (2009) A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock. Genes & Development, Vol. 23. 2009, pp. 708-718.
  Maier, Bert; Wendt, Sabrina; Vanselow, Jens T.; Wallach, Thomas; Reischl, Silke; Oehmke, Stefanie; Schlosser, Andreas & Kramer, Achim
  
• (2009) Biochemical evidence for a timing mechanism in Prochlorococcus. Journal of Bacteriology, Vol. 191. 2009, no. 17, pp. 5342-5347.
  Axmann, Ilka M.; Dühring, Ulf; Seeliger, Luiza; Arnold, Anne; Vanselow, Jens T.; Kramer, Achim & Wilde, Annegret
  
• (2009) Regulation of clock controlled genes in mammals. PLoS ONE, Vol. 4.2009, Issue 3: e4882.
  Bozek, Katarzyna; Relógio, Angela; Kielbasa, Szymon M.; Heine, Markus; Dame, Christof; Kramer, Achim & Herzel, Hanspeter
  
• (2009) Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2. PLoS Biology, Vol. 7.2009, Issue 4: e1000094.
  Hennig, Sven; Strauss, Holger M; Vanselow, Katja; Yildiz, Özkan; Schulze, Sabrina; Arens, Julia; Kramer, Achim & Wolf, Eva