Identifizierung von sekretierten Faktoren des suprachiasmatischen Nukleus (SCN), welche circadiane Rhythmen lokomotorischer Aktivität in Säugern steuern

• Applicant: Professor Dr. Achim Kramer
• Subject Area: Neurosciences
• Term: from 2002 to 2006
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5363286

• Final Report Year: 2010

Final Report Abstract

No abstract available

Publications

• (2004) A model of the mammalian circadian oscillator including the REV-ERBalpha module. Genome Informatics, Vol. 15. 2004, No. 1, pp. 3-12.
  Becker-Weimann S., Wolf J., Kramer A., Herzel H.
  (See online at https://doi.org/10.11234/gi1990.15.3)
• (2004) Modeling feedback loops of the mammalian circadian oscillator. Biophysical Journal, Vol. 87. 2004, Issue 5, pp. 3023–3034.
  Becker-Weimann S, Wolf J, Herzel H, Kramer A
  (See online at https://dx.doi.org/10.1529/biophysj.104.040824)
• (2004) Peroxisomal membrane proteins contain common Pexl9p-binding sites that are an integral part of their targeting signals. Molecular Biology of the Cell, Vol. 15. 2004, no. 7, pp. 3406-3417.
  Rottensteiner H., Kramer A., Lorenzen S., Stein K., Landgraf C., Volkmer-Engert R., Erdmann R.
  (See online at https://dx.doi.org/10.1091/mbc.E04-03-0188)
• (2005) Entrainment in a model of the mammalian circadian oscillator. Journal of Biological Rhythms, Vol. 20. 2005, no. 1, pp. 83-93.
  Geier F., Becker-Weimann S., Kramer A., Herzel H.
  (See online at https://dx.doi.org/10.1177/0748730404269309)
• (2005) Mapping of phosphorylation sites by a multi-protease approach with highly specific phosphopeptide enrichment and nanoLC-MS/MS analysis. Analytical Chemistry, Vol. 77. 2005, Issue 16, pp. 5243–5250.
  Schlosser A., Vanselow J., Kramer A.
  (See online at https://dx.doi.org/10.1021/ac050232m)
• (2005) Spontaneous synchronisation of coupled circadian oscillators. Biophysical Journal, Vol. 89. 2005, Issue 1, pp. 120–129.
  Gonze D., Bemard S., Waltermann C., Kramer A., Herzel H.
  (See online at https://dx.doi.org/10.1529/biophysj.104.058388)
• (2006) Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes & Development, Vol. 20. 2006, Issue 19, pp. 2660-2672.
  Vanselow K., Vanselow J.T., Westermark P.O., ReischI S., Maier B., Korte T., Herrmann A., Herzel H., Schlosser A., Kramer A.
  (See online at https://dx.doi.org/10.1101/gad.397006)
• (2006) Molecular basis for the binding polyspecific ity of an anti-cholera toxin peptide 3 monoclonal antibody. Journal of Molecular Recognition, Vol.19. 2006, Issue 1, pp. 49–59.
  Otte L., Knaute T., Schneider-Mergener J., Kramer A.
  (See online at https://dx.doi.org/10.1002/jmr.757)
• (2007) Comprehensive phosphorylation site analysis of individual phosphoproteins applying scoring schemes for MS/MS data. Analytical Chemistry, Vol. 79. 2007, Issue 19, pp. 7439–7449.
  Schlosser A., Vanselow J., Kramer A.
  (See online at https://dx.doi.org/10.1021/ac0707784)
• (2007) Promoter analysis of mammalian clock controlled genes. Genome Informatics, Vol. 18.2007, pp. 65-74.
  Bozek K., Kielbasa S.M., Kramer A., Herzel H.
  (See online at https://doi.org/10.11234/gi1990.18.65)
• (2007) Structure of an anti-cholera toxin antibody Fab in complex with an epitopederived D-peptide: a case of polyspecific recognition. Journal of Molecular Recognition, Vol. 20. 2007, Issue 4, pp. 263–274.
  Scheerer P., Kramer A., Otte L., Seifert M., Wessner H., Scholz C., Krauß N., Schneider-Mergener J., Höhne W.
  (See online at https://dx.doi.org/10.1002/jmr.838)
• (2008) Global parameter search reveals design principles of the mammalian circadian clock. BMC Systems Biology, Vol. 2.2008,:22.
  Locke J.C.W., Westermark P.O., Kramer A., Herzel H.
  (See online at https://dx.doi.org/10.1186/1752-0509-2-22)
• (2008) Molecular insights into human daily behaviour. Proceedings of the National Academy of Sciences of the USA, Vol. 105 no. 5, pp. 1602–1607.
  Brown S.A., Kunz D., Dumas A., Westermark P.O., Vanselow K,. Tilmann-Wahnschaffe A., Herzel H., Kramer A.
  (See online at https://dx.doi.org/10.1073/pnas.0707772105)
• (2009) A circadian clock in macrophages controls inflammatory immune responses. Proceedings of the National Academy of Sciences of the United States of America (PNAS), vol. 106.2009, no. 50, pp. 21407–21412.
  Keller M., Mazuch J., Abraham U., Eom G.D., Herzog E.D., Volk H.D., Kramer A., Maier B.
  (See online at https://dx.doi.org/10.1073/pnas.0906361106)
• (2009) A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock. Genes & Development, Vol. 23. 2009, pp. 708-718.
  Maier B., Wendt S., Vanselow J.T., Wallach T., ReischI S., Oehmke S., Schlosser A., Kramer A.
  (See online at https://dx.doi.org/10.1101/gad.512209)
• (2009) Biochemical evidence for a timing mechanism in Prochlorococcus. Journal of Bacteriology, Vol. 191. 2009, no. 17, pp. 5342-5347.
  Axmann I.M., Dühring U., Seeliger L., Amold A., Vanselow J.T., Kramer A., Wilde A.
  (See online at https://dx.doi.org/10.1128/JB.00419-09)
• (2009) Regulation of clock controlled genes in mammals. PLoS ONE, Vol. 4.2009, Issue 3: e4882.
  Bozek K., Kielbasa S.M., Relogio A., Heine M., Dame C., Kramer A., Herzel H.
  (See online at https://dx.doi.org/10.1371/journal.pone.0004882)
• (2009) Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2. PLoS Biology, Vol. 7.2009, Issue 4: e1000094.
  Hennig S., Strauss H.M., Vanselow K., Yildiz Ö., Schulze S., Arens J., Kramer A., Wolf E.
  (See online at https://dx.doi.org/10.1371/journal.pbio.1000094)