Selection of prebiotic building blocks by cyclic phase transitions (A06)

• Subject Area: Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 521256690

We develop the non-equilibrium thermodynamic theory to investigate the selection propensity of cyclic phase transitions (freeze-thaw or liquid-liquid co-existance) for the assembly of building blocks essential to life. Specifically, we will apply our theory to minimalistic auto-catalytic reactions, the formation of long homopolymeric linear aggregates such as fatty acids, and the formation of DNA and RNA. We will determine the optimal physicochemical conditions for different cycle properties to obtain specific replication rates, length distributions, and sequence distributions. Our project is fundamental for future studies that screen for functional sequences capable of simple folds or complex functionalities such as self-replication.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 392: Molecular evolution in prebiotic environments
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Christoph Weber, since 1/2024