DNA-methylation reprogramming during early embryogenesis

• Antragsteller: Professor Dr. Jörn E. Walter
• Fachliche Zuordnung: Humangenetik
• Förderung: Förderung von 2002 bis 2010
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5370898

• Erstellungsjahr: 2010

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2002) DNA methylation at promoter regions regulates the timing of gene activation in Xenopus laevis embryos. Dev Biol, 243, 155-165
  Stancheva, I., El-Maarri, O., Walter, J., Niveleau, A. and Meehan, R.R.
  
• (2002) DNA-methylation analysis by the bisulfite-assisted genomic sequencing method. Methods Mol Biol, 200, 143-154
  Hajkova, P., el-Maarri, O., Engemann, S., Oswald, J., Olek, A. and Walter, J.
  
• (2002) Epigenetic reprogramming in mouse primordial germ cells. Mech Dev, 117, 15
  Hajkova, P., Erhardt, S., Lane, N., Haaf, T., El-Maarri, O., Reik, W., Walter, J. and Surani, M.
  
• (2003) Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions. Hum Mol Genet, 12, 295-305
  Lopes, S., Lewis, A., Hajkova, P., Dean, W., Oswald, J., Ferne. T, Murrell. A., Constancia, M., Bartolomei, M., Walter, J. and Reik, W.
  
• (2003) Resistance of lAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis, 35, 88-93
  Lane, N., Dean, W., Erhardt, S., Hajkova, P., Surani, A., Walter, J. and Reik, W.
  
• (2004). "Differential dynamics of histone H3 methylation at positions K4 and K9 in the mouse zygote." BMC developmental biology 4: 12
  Lepikhov, K. and J. Walter
  
• (2008). "Evidence for conserved DNA and histone H3 methylation reprogramming in mouse, bovine and rabbit zygotes." Epigenetics & chromatin 1(1): 8
  Lepikhov, K., Zakhartchenko, V., Hao, R., Yang, F., Wrenzycki, C., Niemann, H., Wolf, E. and Walter, J.
  
• (2009) "Effect of IVF and laser zona dissection on DNA methylation pattern of mouse zygotes". Mammalian Genome 2009, 20(9-10): 664-73
  Peters, D., Lepikhov, K., Rodenacker, K., Marschall, S., Boersma, A., Hutzler, P., Scherb, H., Walter, J. and de Angelis, M. H.
  
• (2009). "Epigenetic modifications and related mRNA expression during bovine oocyte in vitro maturation." Reproduction, fertility, and development 21(6): 738-48
  Racedo, S. E., Wrenzycki, C, Lepikhov, K., Salamone, D., Walter, J. and Niemann, H.
  
• (2010) "DNA demethylation and DNA repair in mouse zygotes". Embo J. 2010, 29(11):1877-88
  Wossidlo, M., Arand, J., Sebastiano, V., Lepikhov, K., Boiani, M., Reinhardt, H., Scholer, H. and Walter, J.