Biological activity and mode of action of the pasteurella multocida toxin

• Applicant: Professor Dr. Klaus Aktories
• Subject Area: Pharmacology
• Term: from 2002 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5380189

• Final Report Year: 2010

Final Report Abstract

No abstract available

Publications

• 2005. Pasteurella multocida toxin-induced activation of RhoA is mediated via two families of G{alpha} proteins, G{alpha}q and G{alpha}12/13. J. Biol. Chem. 280:36701-36707
  Orth, J.H., Lang, S., Taniguchi, M., and Aktories, K.
  
• 2006. Pasteurella multocida toxin (PMT) activates RhoGTPases, induces actin polymerization and inhibits migration of human dendritic cells, but does not influence macropinocytosis. Int. Immunol. 18:459-464
  Blöcker, D., Berod, L., Fluhr, J.W., Orth, J., Idzko, M., Aktories, K., and Norgauer, J.
  
• 2007. Action of Pasteurella multocida toxin on Ga(q) is persistent and independent of interaction with G-protein-coupled receptors. Cell Signal. 19:2174-2182
  Orth, J.H., Lang, S., Preuss, l., Milligan, G., and Aktories, K.
  
• 2007. Modulation of host cell gene expression through activation of STAT transcription factors by Pasteurella multocida toxin. J. Biol. Chem., 282:3050-3057
  Orth, J.H., Aktories, K., and Kubatzky, K.F.
  
• 2008. Activation of Gai and subsequent uncoupling of receptor-Gai signaling by Pasteurella multocida toxin. J. Biol. Chem. 283:23288-23294
  Orth, J.H., Fester, l., Preuss, l., Agnoletto, L., Wilson, B.A., and Aktories, K.
  
• 2008. Anion secretion evoked by Pasteurella multocida toxin across rat colon. Eur. J. Pharmacol. 583:156-163
  Hennig, B., Orth, J., Aktories, K., and Diener, M.
  
• 2009. Bakterielle Toxine aktivieren GTPasen durch Deamidierung. Biospektrum 05:501-503
  Orth, J., Schmidt, G. and Aktories, K.
  
• 2009. Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins. Cell Signal. 21:551-558
  Preuss, l., Kurig, B., Nurnberg, B., Orth, J.H., and Aktories, K.
  
• 2009. Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation. Proc. Natl. Acad. Sci. U. S. A 106:7179- 7184
  Orth, J.H., Preuss, l., Fester, l., Schlosser, A., Wilson, B.A., and Aktories, K.
  
• 2010. Activation of heterotrimeric G proteins by Pasteurella multocida toxin. In: Toxins and Signalling. 45-50
  Orth, J., and Aktories, K.