In vivo-Untersuchungen über die funktionelle Bedeutung menschlicher ß1- und ß2-Adrenozeptor Polymorphismen

• Applicant: Professor Dr. Gerd Heusch, since 11/2007
• Subject Area: Nephrology
• Term: from 2003 to 2009
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5389165

• Final Report Year: 2009

Final Report Abstract

No abstract available

Publications

• Agonist-specific activation of the β2-adrenoceptor/Gs-protein and β2-adrenoceptor/Gi-protein pathway in adult rat ventricular cardiomyocytes. Brit. J. Pharmacol. 147, 714 - 719 (2006)
  Pönicke K., Gröner F., Heinrich-Hoffmann I. & Brodde O.-E.
  
• Cardiac adrenoceptors: physiological and pathohysiological relevance. J. Pharmacol Sci. 100, 323 - 377 (2006)
  Brodde O.-E., Brück H. & Leineweber K.
  
• In patients chronically treated with metoprolol, the demand of inotropic catecholamine support after coronary artery bypass grafting is determined by the. Arg389Gly-β1-adrenoceptor polymorphism. Naunyn-Schmiedeberg's Arch. Pharmacol. 375, 303 - 309 (2007)
  Leineweber K., Bogedain P., Wolf Ch., Wagner S., Weber M., Jakob H.-G., Heusch G., Philipp T., & Brodde O.-E.
  
• β1 and β2-adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses. Pharmacol. & Ther. 117, 1 - 29 (2008)
  Brodde O.-E.