KFO 129:  Mechanismen der Resistenzentwicklung und Optimierung antiviraler Strategien bei Hepatitis C Virusinfektion unter Einbeziehung integrativer Modelle der Biomathematik und Bioinformatik

• Fachliche Zuordnung: Medizin
• Förderung: Förderung von 2005 bis 2010
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5397647

• Erstellungsjahr: 2013

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Clinical significance of in vitro replication-enhancing mutations of the hepatitis C virus (HCV) replicon in patients with chronic HCV infection. Journal of Infectious Diseases, Vol. 192. 2005, Issue 10, pp. 1710–1719.
  Sarrazin, Christoph; Mihm, Ulrike; Herrmann, Eva; Welsch, Christoph; Albrecht, Mario; Sarrazin, Ulrike; Traver, Stella; Lengauer, Thomas & Zeuzem, Stefan
  
• Amino acid variations in hepatitis C virus p7 and sensitivity to antiviral combination therapy with amantadine in chronic hepatitis C. Antiviral Therapy, Vol. 11. 2006, Issue 4, pp. 507-519.
  U. Mihm, N. Grigorian, C. Welsch, E. Herrmann, B. Kronenberger, et al., W.P. Hofmann, M. Albrecht, T. Lengauer, S. Zeuzem, C. Sarrazin
  
• Dynamics of apoptotic activity during antiviral treatment of patients with chronic hepatitis C. Antiviral Therapy, Vol. 12. 2007, Issue 5, pp. 779-787.
  B. Kronenberger, S. Zeuzem, C. Sarrazin, U. Mihm, W.P. Hofmann, E. Herrmann et al.
  
• Mutagenic effect of ribavirin on hepatitis C nonstructural 5B quasispecies in vitro and during antiviral therapy. Gastroenterology, Vol. 132. 2007, Issue 3, pp. 921-930.
  Hofmann, Wolf Peter; Polta, Andreas; Herrmann, Eva; Mihm, Ulrike; Kronenberger, Bernd; Sonntag, Tanja; Lohmann, Volker; Schönberger, Barbara; Zeuzem, Stefan & Sarrazin, Christoph
  
• Somatic hypermutation and mRNA expression levels of the BCL-6 gene in patients with hepatitis C virus-associated lymphoproliferative diseases. Journal of Viral Hepatitis, Vol. 14. 2007, Issue 7, pp. 484-491.
  Hofmann, W. P.; Fernandez, B.; Herrmann, E.; Welsch, C.; Mihm, U.; Kronenberger, B.; Feldmann, G.; Spengler, U.; Zeuzem, S. & Sarrazin, C.
  
• Structural and functional comparison of the non-structural protein 4B in flaviviridae. Journal of Molecular Graphics and Modelling, Vol. 26. 2007, Issue 2, pp. 546-557.
  Welsch, Christoph; Albrecht, Mario; Maydt, Jochen; Herrmann, Eva; Welker, Martin Walter; Sarrazin, Christoph; Scheidig, Axel; Lengauer, Thomas & Zeuzem, Stefan
  
• Clinical relevance of the 2'-5'-oligoadenylate synthetase/RNase L system for treatment response in chronic hepatitis C. Journal of Hepatology, Vol. 50. 2009, Issue 1, pp. 49-58.
  Mihm, Ulrike; Ackermann, Oliver; Welsch, Christoph; Herrmann, Eva; Hofmann, Wolf Peter; Grigorian, Natalia; Welker, Martin Walter; Lengauer, Thomas; Zeuzem, Stefan & Sarrazin, Christoph
  
• Comparison of Envelope 2 CD81 binding regions in PBMC-derived versus serum-derived hepatitis C virus isolates: higher conservation of CD81 region 2 in PBMC isolates. Journal of Viral Hepatitis, Vol. 18. 2011, Issue 3, pp. 181-192.
  Welker, M.-W.; Welsch, C.; Ochs, D.; Hofmann, W. P.; Herrmann, E.; Piiper, A.; Hartmann, R. W.; Zeuzem, S.; Sarrazin, C. & Kronenberger, B.
  
• Impact of ribavirin on HCV replicon RNA decline during treatment with interferon-α and the protease inhibitors boceprevir or telaprevir. Antiviral Therapy, Vol. 16. 2011, Issue 5, pp. 695-704.
  Hofmann, Wolf Peter; Chung, Tje Lin; Osbahr, Carola; Susser, Simone; Karey, Ursel; Mihm, Ulrike; Welsch, Christoph; Lötsch, Jörn; Sarrazin, Christoph; Zeuzem, Stefan & Herrmann, Eva
  
• Role of nucleoside transporters SLC28A2/3 and SLC29A1/2 genetics in ribavirin therapy: protection against anemia in patients with chronic hepatitis C. Pharmacogenetics and Genomics, Vol. 21. 2011, Issue 5, pp. 289-296.
  Doehring, Alexandra; Hofmann, Wolf Peter; Schlecker, Christina; Zeuzem, Stefan; Sarrazin, Christoph; Berg, Thomas; Müller, Tobias; Herrmann, Eva; Geisslinger, Gerd & Lötsch, Jörn